Sphingosine-1-phosphate

Effect of sphingosine-1-phosphate and myoblast transplantation on rat acute myocardial infarction

H. Yu, Chen, P. L., Zhao, Y., Gu, X., He, W., and Gong, Z., Effect of sphingosine-1-phosphate and myoblast transplantation on rat acute myocardial infarction, vol. 14, pp. 13843-13851, 2015.

In this study, we investigated the effects of sphingosine-1-phosphate (S1P) combined with myoblast transplantation on the treatment of acute myocardial infarction and provided a foundation for its clinical application. A rat model of acute myocardial infarction was established by ligating the anterior descending branch of the coronary artery. Serum-free media, myoblasts, myoblasts with S1P liposomes, or myoblasts with liposomes were then injected into the infarcted area.

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