Spinal cord injury

Effect of nimodipine on rat spinal cord injury

Y. - F. Jia, Gao, H. - L., Ma, L. - J., and Li, J., Effect of nimodipine on rat spinal cord injury, vol. 14, pp. 1269-1276, 2015.

We evaluated the potentially protective effect of nimodipine on rat spinal cord injury. Sprague-Dawley rats received spinal cord injury, and were separated into nimodipine (N = 12) and saline groups (N = 12). Within 1 h of the injury, rats were treated intraperitoneally with nimodipine (1.0 mg/kg) or an equal amount of saline. Treatment was performed 3 times a day for 1 week. Operation BBB score and track experiment were used to measure the physical function of the hind legs 1 and 2 weeks after injury.

Effects of musk ketone on nerve recovery after spinal cord injury

L. Guo, Quan, Z. X., Zhao, Z. H., Tang, K., Ou, Y. S., and Jiang, D. M., Effects of musk ketone on nerve recovery after spinal cord injury, vol. 14, pp. 2958-2963, 2015.

The present study aimed to determine the effects of musk ketone on nerve recovery in rats after spinal cord injury. A total of 105 SD female rats were used to establish the rat with dorsal spinal cord injury model (modified Allen’s method). The rats weighed from 200 to 250 g and were provided by the Experimental Animal Center of Chongqing Medical University. They were randomly divided into five treatment groups: saline (NS group), methylprednisolone (MP group), and musk ketone groups (MO1, MO2, and MO3 groups).

Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats

Y. - H. Qi, Yao, W. - L., Zhang, C. - H., and Guo, Y. - Q., Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats, vol. 13, pp. 1366-1372, 2014.

This study investigated cadherin-1 (Cdh1) expression in the sensorimotor cortex of rats after spinal cord injury (SCI). The repairing effect of Cdh1 was evaluated by silencing its expression with lentivirus-mediated RNAi. Twenty male Sprague-Dawley (SD) rats were randomly divided into a normal group and an operation group. Rats of the operation group were given SCI by the Allen method (T10-T11). Cdh1 expression in the sensorimotor cortex was examined by quantitative real-time polymerase chain reaction (PCR) and Western blot analysis.

Influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury

Z. Li, Guo, G. - H., Wang, G. - S., Guan, C. - X., and Yue, L., Influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury, vol. 13, pp. 6083-6092, 2014.

We examined the influence of neural stem cell transplantation on angiogenesis in rats with spinal cord injury. Sixty rats with spinal cord injury were divided into an experimental group and a control group and given neural stem cells or an equivalent amount of phosphate-buffered saline by intravenous transplantation, respectively.

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