Spinal cord injury

STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis

Y. X. Wu, Gao, C. Z., Fan, K. L., Yang, L. M., Mei, X. F., Wu, Y. X., Gao, C. Z., Fan, K. L., Yang, L. M., Mei, X. F., Wu, Y. X., Gao, C. Z., Fan, K. L., Yang, L. M., and Mei, X. F., STAT1 inhibitor alleviates spinal cord injury by decreasing apoptosis, vol. 15, p. -, 2016.

Spinal cord injury (SCI) is typically caused by trauma or disease, and it severely affects patients’ motor function. The relationship between signal transducers and activators of transcription-1 (STAT1) and neuronal death after cerebral focal ischemia has been comprehensively studied, but its role in SCI remains largely unknown. This study investigated the protective effect of an STAT1 inhibitor on SCI. Thirty SD rats were SCI-induced and were then randomly divided into two groups (N = 15 each), either receiving STAT1 or the STAT1 inhibitor S1491 by intraperitoneal injection.

Effectiveness of muscle basal lamina carrying neural stem cells and olfactory ensheathing cells in spinal cord repair

X. W. Kang, Hu, J. L., Wang, S. K., and Wang, J., Effectiveness of muscle basal lamina carrying neural stem cells and olfactory ensheathing cells in spinal cord repair, vol. 14, pp. 13437-13455, 2015.

We examined the effect of muscle basal lamina (MBL) with neural stem cells (NSCs) and olfactory ensheathing cells (OECs) on spinal cord injury repair. Seventy-two Sprague-Dawley rats were subjected to spinal cord hemisection and divided into 6 groups. In blank control group (group A), the ends of the spinal cord hemisection model were flushed with physiological saline.

Improvements in neuroelectrophysiological and rear limb functions in rats with spinal cord injury after Schwann cell transplantation in combination with a C5a receptor antagonist

S. - Q. Zhang, Wu, M. - F., Peng, C. - G., Lv, Y., Wu, D. - K., Liu, J., and Yang, Q., Improvements in neuroelectrophysiological and rear limb functions in rats with spinal cord injury after Schwann cell transplantation in combination with a C5a receptor antagonist, vol. 14, pp. 15158-15168, 2015.

We measured the effect of Schwann cell transplantation and complement factor 5a (C5a) receptor antagonist on nerve function recovery in rats with spinal cord injury. Experimental spinal cord injury was induced in eighty Wistar rats and these were randomly divided into four treatment groups: culture medium and saline injection (control group), Schwann cell injection (cell transplantation group), C5a receptor antagonist injection (C5a receptor antagonist group), and both Schwann cell and C5a receptor antagonist injections (combination group).

Effect of neural stem cell transplantation combined with erythropoietin injection on axon regeneration in adult rats with transected spinal cord injury

Y. Zhao, Zuo, Y., Wang, X. L., Huo, H. J., Jiang, J. M., Yan, H. B., and Xiao, Y. L., Effect of neural stem cell transplantation combined with erythropoietin injection on axon regeneration in adult rats with transected spinal cord injury, vol. 14, pp. 17799-17808, 2015.

We investigated the effect of neural stem cells (NSC) and erythropoietin (EPO) on axon regeneration in adult rats with transected spinal cord injury, and provided an experimental basis for clinical treatment. Forty Wistar rats with T10-transected spinal cord injury were randomly divided into four groups of ten rats: a control group (group A), an NSC-transplant group (group B), an NSC-transplant and EPO group (group C), and an EPO group (group D).

Protective effect and mechanism of probucol in the treatment of spinal cord injury

W. B. Zhu, Wang, Y. H., Sun, G. F., and Wu, J. H., Protective effect and mechanism of probucol in the treatment of spinal cord injury, vol. 14, pp. 8029-8037, 2015.

To investigate the effects of probucol on the treatment of spinal cord injury in rat, 80 rats were randomly divided into two groups of 40: a group treated with probucol and a control group. Allen’s method was used to establish a rat model of spinal cord injury. After establishment, probucol (500 mg·kg-1·day-1) was intraperitoneally injected into the treatment group rats for 1 week, while the same amount of saline was used to treat the control group.

Local expression and role of BMP-2/4 in injured spinal cord

Z. S. Cui, Zhao, P., Jia, C. X., Liu, H. J., Qi, R., Cui, J. W., Cui, J. H., Peng, Q., Lin, B., and Rao, Y. J., Local expression and role of BMP-2/4 in injured spinal cord, vol. 14, pp. 9109-9117, 2015.

We investigated local changes in BMP-2/4 expression in rat spinal cords 1 week following injury to study the damage effects of BMP-2/4 in spinal cord injury (SCI). Sprague Dawley rats (45, 4 months old) were randomized into three groups comprising 15 rats each: a SHAM group, an SCI without noggin group (SCIO), and an SCI with noggin group (SCID). The SCIO and SCID groups were subjected to spinal cord hemisection, and motor activity was assessed using the BBB score.

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