Splicing variants

Luteinizing hormone receptor splicing variants in bovine Leydig cells

T. H. Ma, Xiong, Q. H., Yuan, B., Jiang, H., Gao, Y., Xu, J. B., Liu, S. Y., Ding, Y., Zhang, G. L., Zhao, Y. M., and Zhang, J. B., Luteinizing hormone receptor splicing variants in bovine Leydig cells, vol. 11, pp. 1721-1730, 2012.

The luteinizing hormone receptor (LHR) plays a key role in testosterone production through its interaction with the gonadotropins, LH and chorionic gonadotropin. We examined the LHR splicing pattern in bovine Leydig cells; LH-induced expression of eight cloned splicing variants was detected by real-time PCR. Luteinizing hormone applied to cultured Leydig cells resulted in expression of full-length LHR and the A and B isoforms, as well as secretion of testosterone, which first increased, then declined, and then increased further, with increased LH levels.

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