Luteinizing hormone receptor splicing variants in bovine Leydig cells
“Luteinizing hormone receptor splicing variants in bovine Leydig cells”, vol. 11, pp. 1721-1730, 2012.
, The luteinizing hormone receptor (LHR) plays a key role in testosterone production through its interaction with the gonadotropins, LH and chorionic gonadotropin. We examined the LHR splicing pattern in bovine Leydig cells; LH-induced expression of eight cloned splicing variants was detected by real-time PCR. Luteinizing hormone applied to cultured Leydig cells resulted in expression of full-length LHR and the A and B isoforms, as well as secretion of testosterone, which first increased, then declined, and then increased further, with increased LH levels.