Spontaneous abortions

Molecular karyotyping of 1,295 spontaneous consecutive abortions by sequential analysis with QF-PCR, HGQ-PCR and SNP-array

C. S. de Sousa, Pena, H. B., Rocha, J. L. F., and Pena, S. D. J., “Molecular karyotyping of 1,295 spontaneous consecutive abortions by sequential analysis with QF-PCR, HGQ-PCR and SNP-array”, Genetics and Molecular Research, vol. 21, no. 3, 2022.

Detection of aneuploidies in spontaneous abortions by quantitative fluorescent PCR with short tandem repeat markers: a retrospective study

F. F. Coelho, Marques, F. K., Gonçalves, M. S., Almeida, V. C. O., Mateo, E. C. C., Ferreira, A. C. S., Coelho, F. F., Marques, F. K., Gonçalves, M. S., Almeida, V. C. O., Mateo, E. C. C., and Ferreira, A. C. S., “Detection of aneuploidies in spontaneous abortions by quantitative fluorescent PCR with short tandem repeat markers: a retrospective study”, vol. 15, p. -, 2016.

Approximately 10-15% of all pregnancies end in spontaneous abortions. Many factors can lead to embryonic loss; however, it has been well established that over 50% of all miscarriages result from chromosomal abnormalities, primarily aneuploidies (>96%). Identifying the cause of miscarriage can significantly reduce the psychological stress in women, and enable better genetic counseling for a future pregnancy. Quantitative fluorescent polymerase chain reaction (QF-PCR) has been previously used in the study of chromosomal abnormalities.

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