Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats
“Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats”, vol. 14, pp. 5896-5909, 2015.
, Hypoxia-inducible factor-1α (HIF-1α) has been identified as a transcription factor that is involved in diverse physiological and pathological processes in the ovary. In this study, we examined whether HIF-1α is expressed in a cell- and stage-specific manner during follicular growth and development in the mammalian ovaries. Using immunohistochemistry and Western blot analysis, HIF-1α expression was observed in granulosa cells specifically and was significantly increased during the follicular growth and development of postnatal rats.