Alleviation of streptozotocin-induced diabetes in nude mice by stem cells derived from human first trimester umbilical cord
“Alleviation of streptozotocin-induced diabetes in nude mice by stem cells derived from human first trimester umbilical cord”, vol. 14, pp. 12505-12519, 2015.
, Cells isolated from human first trimester umbilical cord perivascular layer (hFTM-PV) tissues display the pluripotent characteristics of stem cells. In this study, we examined whether hFTM-PV cells can differentiate into islet-like clusters (ILCs) in vitro, and whether transplantation of the hFTM-PV cells with and without differentiation in vitro can alleviate diabetes in nude mice. The hFTM-PV cells were differentiated into ILCs in vitro through a simple stepwise culture protocol.