Stem cell

Alleviation of streptozotocin-induced diabetes in nude mice by stem cells derived from human first trimester umbilical cord

M. Cao, Zhang, J. B., Dong, D. D., Mou, Y., Li, K., Fang, J., Wang, Z. Y., Chen, C., Zhao, J., and Yie, S. M., Alleviation of streptozotocin-induced diabetes in nude mice by stem cells derived from human first trimester umbilical cord, vol. 14, pp. 12505-12519, 2015.

Cells isolated from human first trimester umbilical cord perivascular layer (hFTM-PV) tissues display the pluripotent characteristics of stem cells. In this study, we examined whether hFTM-PV cells can differentiate into islet-like clusters (ILCs) in vitro, and whether transplantation of the hFTM-PV cells with and without differentiation in vitro can alleviate diabetes in nude mice. The hFTM-PV cells were differentiated into ILCs in vitro through a simple stepwise culture protocol.

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