Stem cell differentiation

Isolation, proliferation, and induction of Bama mini-pig spermatogonial stem cells in vitro

H. M. Zhao, Yang, H., Luo, F. H., Li, M. X., Zhang, S., Yang, X. G., Lu, Y. Q., Lu, S. S., Wu, Y. J., Lu, K. H., Zhao, H. M., Yang, H., Luo, F. H., Li, M. X., Zhang, S., Yang, X. G., Lu, Y. Q., Lu, S. S., Wu, Y. J., and Lu, K. H., “Isolation, proliferation, and induction of Bama mini-pig spermatogonial stem cells in vitro”, vol. 15, p. -, 2016.

Spermatogonial stem cells (SSCs), the unique seed cells of testes, can undergo meiosis and form spermatozoa, thus transmitting genetic information to offspring. Research concerning these cells explores the mechanism underlying spermatogenesis, making possible the induction of their differentiation into spermatozoa in vitro. SSCs have therefore attracted much interest among scientists. Although the proliferation of such cells in vitro has been demonstrated, we are unaware of any long-term laboratory culture of porcine SSCs.

Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells

J. Y. Zhang and Li, L. C., “Genetic expression and functional characterization of the RUNX2 gene in human adult bone marrow mesenchymal stem cells”, vol. 14, pp. 18210-18217, 2015.

Past studies have revealed the critical role of runt-related transcription factor 2 (RUNX2) in the proliferation and differentiation of mesenchymal stem cells (MSCs). This study therefore aimed to investigate the expression profile of the RUNX2 gene in human bone marrow MSCs and its biological characteristics. Bone marrow MSCs were separated from 12 patients who had received hip joint replacement surgery.

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