Systemic lupus erythematosus

Balance between inflammatory and regulatory cytokines in systemic lupus erythematosus

Y. Yao, Wang, J. B., Xin, M. M., Li, H., Liu, B., Wang, L. L., Wang, L. Q., Zhao, L., Yao, Y., Wang, J. B., Xin, M. M., Li, H., Liu, B., Wang, L. L., Wang, L. Q., and Zhao, L., “Balance between inflammatory and regulatory cytokines in systemic lupus erythematosus”, vol. 15, p. -, 2016.

To investigate the cytokine profile in serum and cerebrospinal fluid (CSF) from patients with systemic lupus erythematosus (SLE) and central nervous system infection, we measured interferon-g (IFN-g), interleukin-1b (IL-1b), IL-4, IL-6, IL-8, IL-10, and IL-17 levels in serum and CSF from 50 SLE patients and 38 matched controls.

Vulnerability of atherosclerotic plaques is as­sociated with type I interferon in a murine model of lupus and atherosclerosis

C. Y. Zhang, Qu, B., Ye, P., Li, J., and Bao, C. D., “Vulnerability of atherosclerotic plaques is as­sociated with type I interferon in a murine model of lupus and atherosclerosis”, vol. 14, pp. 14871-14881, 2015.

This study aimed to investigate the relationship between type I interferon (IFN-I) and plaque stability in pristane-treated apolipoprotein E-knockout (ApoE-/-) mice. Antinuclear antibody (ANA) and extractable nuclear antigen antibody (ENA) levels were measured by immunofluorescence and enzyme-linked immunospot assay. Atherosclerotic plaques were detected by Sirius red/fast green staining. Cell apoptosis was detected by terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick-end labeling. Gene expression was determined by real-time PCR analyses.

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