Tanshinone IIA

Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors

B. X. Ren, Ji, Y., Tang, J. C., Sun, D. P., Hui, X., Yang, D. Q., and Zhu, X. L., Effect of Tanshinone IIA intrathecal injections on pain and spinal inflammation in mice with bone tumors, vol. 14, pp. 2133-2138, 2015.

The study aimed to investigate the effect of intrathecal injections of Tanshinone IIA on thermal hyperalgesia in a mouse model of bone cancer-pain. Spinal IL-1β, IL-6, TNF-α expression levels were analyzed. C3H/HeNCrlVr male mice were assigned to groups that either received dose-dependent injections of Tanshinone IIA, or the DMSO + Sham, Tanshinone IIA + Sham, DMSO + Tumor, and Control groups. Paw withdrawal thermal latency (PWTL) was measured with a radiant heat stimulus and mRNA expression levels were determined using real-time PCR.

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