Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
“Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.”, vol. 15, p. -, 2016.
, Drug resistance in cells is a major impedance to successful treatment of lung cancer. Taxus chinensis var. inhibits the growth of tumor cells and promotes the synthesis of interleukins 1 and 2 and tumor necrosis factor, enhancing immune function. In this study, T. chinensis var.-induced cell death was analyzed in lung cancer cells (H460) enriched for stem cell growth in a defined serum-free medium. Taxus-treated stem cells were also analyzed for Rhodamine 123 (Rh-123) expression by flow cytometry, and used as a standard functional indicator of MDR.