TCF7L2

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

Y. Yang, Xu, J. R., Wang, Y. J., and Liu, X. M., Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population, vol. 14, pp. 10064-10071, 2015.

Diabetes is one of costly chronic diseases. Previous studies across several ethnicities have shown that polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene were strongly associated with susceptibility to type 2 diabetes (T2DM). In the present study, the association between the TCF7L2 gene and the susceptibility to T2DM in a Chinese Hui population was interrogated.

Transcription factor 7-like 2 polymorphisms and diabetic retinopathy: a systematic review

P. Sudchada and Scarpace, K., Transcription factor 7-like 2 polymorphisms and diabetic retinopathy: a systematic review, vol. 13, pp. 5865-5872, 2014.

The global prevalence of type 2 diabetes mellitus (T2DM) has increased, as well as complications including diabetic retinopathy. Polymorphisms in transcription factor 7-like 2 (TCF7L2) have been associated with T2DM, with the strongest association attributed to the single-nucleotide polymorphism rs7903146. In this review, we searched the current literature to determine whether an association exists between TCF7L2 polymorphisms rs7903146 with diabetic retinopathy.

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

C. M. A. R. Barros, Araújo-Neto, A. P., Lopes, T. R., Barros, M. A. L., Motta, F. J. N., Canalle, R., Nunes, L. C. C., Rey, J. A., Burbano, R. R., Lima-Barros, M. A., Yoshioka, F. K. N., and Pinto, G. R., Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil, vol. 13, pp. 7889-7898, 2014.

Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D.

Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population

W. Wei, Jiang, M., Luo, L., Li, Z., Wang, P., and Dong, W. Q., Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population, vol. 12, pp. 6268-6274, 2013.

Recent genome wide association studies (GWAS) and candidate gene studies have revealed many novel loci associated with colorectal cancer susceptibility. We evaluated the effect of these colorectal cancer-associated variants on the risk of breast cancer in a Chinese Han population.

Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in

P. N. Mukhopadhyaya, Acharya, A., Chavan, Y., Purohit, S. S., and Mutha, A., Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in, vol. 9, pp. 2060-2068, 2010.

A population-based study was undertaken to evaluate linkage between single-nucleotide polymorphisms known as risk factors and type 2 diabetes in an Indian population. The study population was comprised of 40 normal glucose-tolerant individuals (21 males and 19 females) and 40 type 2 diabetes patients (21 males and 19 females). The genes and their corresponding single-nucleotide polymorphisms that we screened were VDR (rs 731236 and rs 1544410), IL-6 (rs 1800795), TCF7L2 (rs 7903146) and TNF-α (rs 1800629).

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