Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha
“Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha”, vol. 14, pp. 11771-11779, 2015.
, Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock factor-1 (HSF1) protein, respectively, in glioma cells. Radioimmunoassay was used to dynamically monitor the contents of TNF-α in the nutrient fluid of C6 cells after thermotherapy treatment.