Thyroid

Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?

H. I. Gözü, Özçelik, S., Aloğlu, M., Şahin, A., Temiz, S., Dayan, A., Cengiz, H., Tütüncü, Y., Bircan, R., Gözü, H. I., Özçelik, S., Aloğlu, M., Şahin, A., Temiz, S., Dayan, A., Cengiz, H., Tütüncü, Y., and Bircan, R., Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?, vol. 15, p. -, 2016.

The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkish population. We investigated the TSHR D727E polymorphism in 123 patients and 97 healthy subjects using the polymerase chain reaction-restriction fragment length polymorphism technique.

Characterization and significance of MUC1 and c-myc expression in elderly patients with papillary thyroid carcinoma

Y. - J. Hu, Luo, X. - Y., Yang, Y., Chen, C. - Y., Zhang, Z. - Y., and Guo, X., Characterization and significance of MUC1 and c-myc expression in elderly patients with papillary thyroid carcinoma, vol. 14, pp. 15325-15330, 2015.

The aim of this study was to examine the expression of mucin 1 (MUC1) and c-myc and the significance thereof in elderly patients with papillary thyroid carcinoma. The expression levels of MUC1 and c-myc were examined by immunohistochemical methods in 58 patients with papillary thyroid carcinoma, 35 with nodular goiter, and 30 subjects with normal thyroid tissue. The positive rate of MUC1 detection in papillary thyroid carcinoma was 77.6% (45/58), while it was 90.0% (9/10) in those with infiltration and 88.2% (15/17) in those with lymphatic metastasis.

Subscribe to Thyroid