Thyroid cancer

Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development

T. Zara-Lopes, Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., Goloni-Bertollo, E. M., Zara-Lopes, T., Gimenez-Martins, A. P. A., Nascimento-Filho, C. H. V., Castanhole-Nunes, M. M. U., Galbiatti-Dias, A. L. S., Padovani-Júnior, J. A., Maniglia, J. V., Francisco, J. L. E., Pavarino, E. C., and Goloni-Bertollo, E. M., Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development, vol. 15, p. -, 2016.

Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer.

MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis

G. J. Zhou, Xiao, M., Zhao, L. N., Tang, J. G., and Zhang, L., MicroRNAs as novel biomarkers for the differentiation of malignant versus benign thyroid lesions: a meta-analysis, vol. 14, pp. 7279-7289, 2015.

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).

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