TIM-3

Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-κB pathway and epithelial-mesenchymal transition

Z. M. Feng, Guo, S. M., Feng, Z. M., and Guo, S. M., “Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-κB pathway and epithelial-mesenchymal transition”, vol. 15, p. -, 2016.

The aim of this study was to investigate the expression of T-cell immunoglobulin mucin domain molecule-3 (Tim-3) in osteosarcoma tissues, and analyze its effect on cell proliferation and metastasis in an osteosarcoma cell line. Tim-3 mRNA and protein expression in osteosarcoma tissue was detected by reverse transcriptase-polymerase chain reaction and immunohistochemistry, respectively.

Decreased TIM-3 mRNA expression in peripheral blood mononuclear cells from nephropathy patients

X. Z. Cai, Liu, N., Qiao, Y., Du, S. Y., Chen, Y., Chen, D., Yu, S., and Jiang, Y., “Decreased TIM-3 mRNA expression in peripheral blood mononuclear cells from nephropathy patients”, vol. 14, pp. 6543-6548, 2015.

Increasing evidence shows that TIM-1 and TIM-3 in­fluence chronic autoimmune diseases, and their expression levels in immune cells from nephritic patients are still unknown.

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