Tissue engineering

Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits

Z. J. Wang, An, R. Z., Zhao, J. Y., Zhang, Q., Yang, J., Wang, J. B., Wen, G. Y., Yuan, X. H., Qi, X. W., Li, S. J., and Ye, X. C., Repair of articular cartilage defects by tissue-engineered cartilage constructed with adipose-derived stem cells and acellular cartilaginous matrix in rabbits, vol. 13, pp. 4599-4606, 2014.

After injury, inflammation, or degeneration, articular cartilage has limited self-repair ability. We aimed to explore the feasibility of repair of articular cartilage defects with tissue-engineered cartilage constructed by acellular cartilage matrices (ACMs) seeded with adipose-derived stem cells (ADSCs). The ADSCs were isolated from 3-month-old New Zealand albino rabbit by using collagenase and cultured and amplified in vitro.

Fibroin protein/chitosan scaffolds and bone marrow mesenchymal stem cells culture in vitro

J. Deng, She, R. F., Huang, W. L., Yuan, C., and Mo, G., Fibroin protein/chitosan scaffolds and bone marrow mesenchymal stem cells culture in vitro, vol. 13, pp. 5745-5753, 2014.

A previous experiment demonstrated that fibroin protein and chitosan mixed in proper proportion presented good physical and chemical properties and biological characteristics, which can make up for their respective disadvantages. To observe the growth of bone marrow mesenchymal stem cells (BMSCs) on these fibroin protein/chitosan 3D scaffolds, induced rabbit BMSCs were seeded on fibroin protein/chitosan scaffolds. The cell adhesion rate was measured, and cell growth was observed under an inverted microscope and a scanning electron microscope.

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