TNF-α

TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis

Y. H. Lee and Song, G. G., TNF-α -308 A/G and -238 A/G polymorphisms and susceptibility to glaucoma: a meta-analysis, vol. 14, pp. 4966-4977, 2015.

The purpose of this study was to examine whether tu­mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex­amining the association between TNF-α -308 A/G and -238 A/G poly­morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A al­lele and glaucoma [odds ratio (OR) = 1.403, 95% confidence inter­val (CI) = 0.784-2.513, P = 0.254].

Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α

T. Yu, Lu, Q., Ou, X. L., Cao, D. Z., and Yu, Q., Clinical study on gastric cancer susceptibility genes IL-10-1082 and TNF-α, vol. 13, pp. 10909-10912, 2014.

TNF 308 gene polymorphism and IL-10 polymorphism provided evidence in diagnosing some types of cancer. We aimed to explore the relation of gene polymorphism with gastric cancer. A total of 360 cases of gastric cancer patients were included in the study. The genotypes GG, GA, and AA of the interleukin-10-1082 gene (IL-10-1082) and the tumor necrosis factor-alpha gene (TNF-α) 308 polymorphism were examined by chromogenic detection. Three hundred healthy individuals’ gene as control group were also examined.

Subscribe to TNF-α