TNF-α

Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha

L. J. Qin, Zhang, T., Jia, Y. S., Zhang, Y. B., Zhang, Y. X., and Wang, H. T., Thermotherapy-induced reduction in glioma invasiveness is mediated by tumor necrosis factor-alpha, vol. 14, pp. 11771-11779, 2015.

Thermotherapy has been proven to be effective for the treatment of various tumors, including glioma. We determined whether tumor necrosis factor-alpha (TNF-α) is involved in the regulation of the biological processes of glioma development. Reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry were used to investigate the levels of TNF-α mRNA and heat shock factor-1 (HSF1) protein, respectively, in glioma cells. Radioimmunoassay was used to dynamically monitor the contents of TNF-α in the nutrient fluid of C6 cells after thermotherapy treatment.

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