Toll-like receptor 4

Relationship between TLR4 and CCL2 expression and recurrent spontaneous abortion

P. Li, Wu, H. L., Dong, B. H., Li, P., Wu, H. L., Dong, B. H., Li, P., Wu, H. L., and Dong, B. H., Relationship between TLR4 and CCL2 expression and recurrent spontaneous abortion, vol. 15, p. -, 2016.

The increasing incidence of recurrent spontaneous abortion (RSA) severely affects women’s health. The involvement of the immune system during pregnancy and its contribution to RSA draw researchers’ attention. Both Toll-like receptor 4 (TLR4) and chemokine (C-C motif) ligand 2 (CCL2) have been linked to various pregnancy disorders. In this study, we quantified TLR4 and CCL2 levels in a case-control study in order to elucidate the correlation between these factors and RSA, and the potential to use them as disease markers.

Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study

W. H. Huang, Nie, L. H., Zhang, L. J., Jing, L. P., Dong, F., Wang, M., Zhang, N., Liu, Y., Zhang, B. H., Chen, C., Lin, H. S., Wei, X. C., Yang, G., and Jing, C. X., Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with type 2 diabetes risk in a southern Chinese population: a case-control study, vol. 14, pp. 8694-8705, 2015.

Toll-like receptors (TLRs), the triggers of the innate and adaptive immune responses, are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). Several studies have investigated the effects of genetic polymorphisms in TLR4 and TLR2, but they have yielded limited results. We investigated whether non-missense genetic polymorphisms in the regulatory regions of TLR4 and TLR2 were related to T2DM in a southern Chinese population.

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