Toll-like receptor

Expression of toll-like receptors in hepatic cirrhosis and hepatocellular carcinoma

L. Sun, Dai, J. J., Hu, W. F., Wang, J., Sun, L., Dai, J. J., Hu, W. F., and Wang, J., “Expression of toll-like receptors in hepatic cirrhosis and hepatocellular carcinoma”, vol. 15, p. -, 2016.

Toll-like receptors (TLRs) can specifically identify pathogen-associated molecular patterns (PAMPs) by recognizing structural patterns in diverse microbial molecules, and can provide an effective defense against multiple microbial infectious. A variety of TLRs can be expressed on the surface of liver parenchymal as well as nonparenchymal cells. Kupffer cells are a type of hepatic nonparenchymal macrophage, and are positively associated with the severity of liver fibrosis.

729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer

B. Wan, Tan, J., Zeng, Q., He, L. Y., Gan, Y., Dai, Y. B., and Yao, K., “729G/C polymorphism in Toll-like receptor 4 results in increased susceptibility to bladder cancer”, vol. 14, pp. 15482-15487, 2015.

In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 2008 and February 2014. The TLR4-729G/C polymorphism was detected by the polymerase chain reaction-restriction fragment length polymorphism assay.

Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice

X. X. Li, Jiang, D. Y., Huang, X. X., Guo, S. L., Yuan, W., and Dai, H. P., “Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice”, vol. 14, pp. 17391-17398, 2015.

The specific role of Toll-like receptor 4 (TLR4) in bleomycin-induced lung fibrosis of mice, a model of human idiopathic pulmonary fibrosis, has not been characterized. We injected bleomycin intratracheally into TLR4 knockout (TLR4-/-) and wild-type (WT) mice. Twenty-one days after injection, mice were sacrificed and their lungs were harvested for pathological, hydroxyproline, mRNA expression, and collagen I analyses. Body weight changes and mortality were observed.

Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4

W. Zhou, Lv, H., Li, M. X., Su, H., Huang, L. G., Li, J., and Yuan, W. M., “Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4”, vol. 14, pp. 11505-11514, 2015.

We established a necrotizing enterocolitis (NEC) rat model and explored the role of bifidobacteria in the intestines of the rats and its regulation on intestinal Toll-like receptors (TLRs).

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