Transcobalamin gene

Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China

Y. P. Liao, Zhang, D., Zhou, W., Meng, F. M., Bao, M. S., Xiang, P., and Liu, C. Q., Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China, vol. 13, pp. 1764-1773, 2014.

We examined whether polymorphisms in the methylenetetrahydrofolate dehydrogenase (MTHFD) and transcobalamin (TC) genes, which are involved in folate metabolism, affect maternal risk for Down syndrome. We investigated 76 Down syndrome mothers and 115 control mothers from Bengbu, China. Genomic DNA was isolated from the peripheral lymphocytes. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFD G1958A and TC C776G.

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