Transforming growth factor-β1

Expression of transforming growth factor-β1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue

F. B. Li, Zhao, H., Peng, K. R., Gao, Z. G., Huang, S. J., Tou, J. F., Shu, X. L., Gu, W. Z., Li, F. B., Zhao, H., Peng, K. R., Gao, Z. G., Huang, S. J., Tou, J. F., Shu, X. L., and Gu, W. Z., Expression of transforming growth factor-β1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue, vol. 15, p. -, 2016.

We investigated the expression of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in the liver tissue of infants with congenital biliary atresia and neonatal hepatitis, as well as the relationship between the expression of the two factors and liver fibrosis. Thirty-six infants who met the cholestasis criteria were classified into congenital biliary atresia and neonatal hepatitis groups. All specimens were stained with hematoxylin and eosin and Masson’s trichrome, and the degree of liver fibrosis was assessed.

TGF-β1 polymorphisms and familial aggregation of liver cancer in Guangxi, China

P. Q. Wan, Wu, J. Z., Huang, L. Y., Wu, J. L., Wei, Y. H., and Ning, Q. Y., TGF-β1 polymorphisms and familial aggregation of liver cancer in Guangxi, China, vol. 14, pp. 8147-8160, 2015.

The goal of present study was to investigate the relationship between polymorphisms of TGF-β1 and familial aggregation of liver cancer in Guangxi Zhuang, Han, and Yao populations. We conducted a population-based case-control family study of liver cancer in Guanxi, China. A total of 214 individuals from 37 case families were surveyed for polymorphisms in TGF-β1. We genotyped six functional TGF-β1 polymorphisms: rs1800469, rs2241715, rs2241716, rs11466345, rs8105161, and rs747857.

Association of a transforming growth factor-β1 polymorphism with acute coronary syndrome in a Chinese Han population

Y. N. Yang, Zhao, B., Li, X. M., Xie, X., Liu, F., and Chen, B. D., Association of a transforming growth factor-β1 polymorphism with acute coronary syndrome in a Chinese Han population, vol. 13, pp. 6160-6167, 2014.

Acute coronary syndrome (ACS) is a complex multifactorial and polygenic disorder that is thought to result from the interaction between an individual’s genetic makeup and various environmental factors. The aim of this study was to investigate the association of a transforming growth factor-β1 (TGF-β1) polymorphism (-509C>T) with ACS in a Chinese Han population. The TGF-β1 polymorphism was evaluated in 336 patients with ACS and 396 healthy control subjects by polymerase chain reaction-restriction fragment length polymorphism.

Association of MSX1 and TGF-β1 genetic polymorphisms with hypodontia: meta-analysis

W. Zhang, Qu, H. C., and Zhang, Y., Association of MSX1 and TGF-β1 genetic polymorphisms with hypodontia: meta-analysis, vol. 13, pp. 10007-10016, 2014.

We conducted a comprehensive meta-analysis of 4 case-control studies to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-β1 (TGF-β1) genes and hypodontia. A total of 643 tooth agenesis cases and 733 healthy controls were included in this study. The meta-analysis results showed that the T allele and T carrier (CT + TT) of rs1095 in the MSX1 gene were positively associated with hypodontia susceptibility.

Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients

I. B. Han, Ropper, A. E., Jeon, Y. J., Park, H. S., Shin, D. A., Teng, Y. D., Kuh, S. - U., and Kim, N. - K., Association of transforming growth factor-beta 1 gene polymorphism with genetic susceptibility to ossification of the posterior longitudinal ligament in Korean patients, vol. 12, pp. 4807-4816, 2013.

Ossification of the posterior longitudinal ligaments (OPLL) has been considered to be associated with abnormalities of bone metabolism, and transforming growth factor-β1 (TGF-β1) has been demonstrated to affect the bone remodeling process. We investigated two SNPs of the TGF-β1 promoter (-509C>T; rs1800469) and exon 1 (869T>C; rs1982073) in 298 Koreans (98 patients with OPLL and 200 control subjects). The promoter SNP -509C>T was determined by PCR and RFLP, and the TaqMan probe assay was used to determine 869T>C polymorphism genotypes.

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