TrkA

Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation

Q. Gao, Chen, C. F., Dong, Q., Hou, L., Chen, X., Zhi, Y. L., Li, X., Lu, H. T., and Zhang, H. Y., Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation, vol. 14, pp. 13195-13202, 2015.

Neuroblastoma is the most common and one of the deadliest among pediatric tumors; however, a subset of infants with neuroblastoma display spontaneous regression. The mechanism of spontaneous regression remains to be elucidated. TrkA plays an essential role in the differentiation and functionality of neurons; abundant TrkA expression is associated with favorable prognosis of neuroblastoma. All-trans retinoic acid (ATRA), a first-line drug for acute promyelocytic leukemia (APL) treatment, has been shown to induce differentiation and inhibit cell growth.

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