Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation
“Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation”, vol. 14, pp. 13195-13202, 2015.
, Neuroblastoma is the most common and one of the deadliest among pediatric tumors; however, a subset of infants with neuroblastoma display spontaneous regression. The mechanism of spontaneous regression remains to be elucidated. TrkA plays an essential role in the differentiation and functionality of neurons; abundant TrkA expression is associated with favorable prognosis of neuroblastoma. All-trans retinoic acid (ATRA), a first-line drug for acute promyelocytic leukemia (APL) treatment, has been shown to induce differentiation and inhibit cell growth.