TSC

Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis

F. Zhang, Yang, Y., Hu, D., Lei, H., and Wang, Y., Lack of an association between TSC gene Arg904Gln polymorphisms and essential hypertension risk based on a meta-analysis, vol. 11, pp. 3511-3517, 2012.

Although there have been several studies investigating a possible association between essential hypertension and TSC gene Arg904Gln polymorphisms, the results have been inconsistent. We conducted a meta-analysis of four case-control studies (one study in Europe and three studies in Asia), including 1811 essential hypertension cases and 1381 controls.

Association of TSC gene variants and hypertension in Mongolian and Han populations

P. Y. Chang, Zhao, L. G., and Su, X. L., Association of TSC gene variants and hypertension in Mongolian and Han populations, vol. 10, pp. 902-909, 2011.

We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from the Chinese HapMap database based on pairwise r2 ≥ 0.5 and minor allele frequency ≥0.05. Genotyping was performed using the PCR/ligase detection reaction assay.

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