Molecular characterization and functional analysis of sheep thyroid transcription factor-1
“Molecular characterization and functional analysis of sheep thyroid transcription factor-1”, vol. 11, pp. 2585-2597, 2012.
, Thyroid transcription factor-1 (TTF-1), a member of the Nkx2 family of homeodomain-containing proteins, is involved in binding to and in activating the promoters of several important genes in the thyroid, lungs, and brain, and in regulating expression of these tissue-specific genes. We investigated potential roles of sheep (Ovis aries) TTF-1 in regulating cell fate and organ morphogenesis and in controlling puberty and reproductive capability of females.