Tuberculosis

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

G. Tian, Li, X., Li, H., Wang, X., and Cheng, B., “Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis”, vol. 14, pp. 5501-5510, 2015.

Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The National Center for Biotechnology Information Global Cross Database and Google Scholar database were searched for relative studies.

Genetic polymorphisms in metabolic enzymes and susceptibility to anti-tuberculosis drug-induced hepatic injury

F. M. Feng, Guo, M., Chen, Y., Li, S. M., Zhang, P., Sun, S. F., and Zhang, G. S., “Genetic polymorphisms in metabolic enzymes and susceptibility to anti-tuberculosis drug-induced hepatic injury”, vol. 13, pp. 9463-9471, 2014.

We examined the relationships between N-transacetylase 2 (NAT2), cytochrome P450 (CYP) 2E1 enzyme, glutathione S-transferase M1, T1 (GSTM1/GSTT1) gene polymorphisms, and anti-tuberculosis drug-induced hepatic injury (ADIH). A one-to-one matched case-control study was carried out using clinical data. NAT2, CYP2E1, GSTM1, and GSTT1 polymorphisms were identified in 173 pairs of research subjects. Statistical analysis was performed to determine risk factors of ADIH.

R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran

H. - R. Kouhpayeh, Hashemi, M., Hashemi, S. - A., Moazeni-Roodi, A., Naderi, M., Sharifi-Mood, B., Taheri, M., Mohammadi, M., and Ghavami, S., “R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran”, vol. 11, pp. 1075-1081, 2012.

The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene, which encodes an intracellular lymphoid-specific phosphatase, is considered an important regulator of T-cell activation. We investigated a possible association between the PTPN22 C1858T (R620W) polymorphism and pulmonary tuberculosis in an Iranian population. Single nucleotide polymorphisms of PTPN22 C1858T (rs2476601) were genotyped in 172 pulmonary tuberculosis cases and 204 normal subjects from Zaheden, Iran.

Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population

M. Y. Zhao, Xue, Y., Zhao, Z. Q., Li, F. J., Fan, D. P., Wei, L. L., Sun, X. J., Zhang, X., Wang, X. C., Zhang, Y. X., and Li, J. C., “Association of CD14 G(-1145)A and C(-159)T polymorphisms with reduced risk for tuberculosis in a Chinese Han population”, vol. 11, pp. 3425-3431, 2012.

Although the role of CD14 in mediating signals from Toll-like receptors to recognize Mycobacterium tuberculosis is known, how polymorphisms in this gene affect the susceptibility to develop tuberculosis are still not clear. We examined whether single nucleotide polymorphisms at positions -1145 and -159 in the promoter region of the CD14 gene are associated with tuberculosis in a Chinese Han population in a case-control study of 432 Chinese patients with tuberculosis and 404 ethnically matched healthy controls.

Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran

G. Bahari, Hashemi, M., Taheri, M., Naderi, M., Moazeni-Roodi, A., Kouhpayeh, H. R., and Eskandari-Nasab, E., “Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran”, vol. 12, pp. 160-166, 2013.

Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala) polymorphisms on patient susceptibility to pulmonary tuberculosis (PTB) in a sample of the Iranian population. This case-control study was performed using 150 PTB cases and 150 controls.

Clinical value of surfactant protein-A in serum and sputum for pulmonary tuberculosis diagnosis

H. Hu, Teng, G. L., Gai, L. Z., Yang, Y., and Zhu, C. J., “Clinical value of surfactant protein-A in serum and sputum for pulmonary tuberculosis diagnosis”, vol. 12, pp. 4918-4924, 2013.

The aim of this study was to explore the diagnostic and differential diagnosis value of surfactant protein-A (SP-A) in the serum and sputum for pulmonary tuberculosis. A total of 101 patients with pulmonary tuberculosis, 85 healthy volunteers, and 30 chronic obstructive pulmonary disease (COPD) patients were divided into pulmonary tuberculosis group, healthy control group, and COPD group, respectively. SP-A was determined in the serum and sputum in the three groups by enzyme-linked immunosorbent assay. The expression of SP-A in serum was significantly higher (P 0.05).

Lack of association between MD-2 promoter gene variants and tuberculosis

Y. Xue, Zhao, Z. Q., Hong, D., Zhao, M. Y., Zhang, Y. X., Wang, H. J., Wang, Y., and Li, J. C., “Lack of association between MD-2 promoter gene variants and tuberculosis”, vol. 9, pp. 1584-1590, 2010.

Myeloid differentiation-2 (MD-2) is an essential component of the CD14-TLR4/MD-2 receptor complex involved in microbial cell wall component recognition during infection. Genetic variations in the MD-2 gene may influence human susceptibility to infectious diseases. To date, a predisposition of MD-2 gene variants to contract tuberculosis has not been reported. We investigated whether MD-2 gene polymorphisms were associated with the development of tuberculosis in a Chinese population.

Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population

Y. X. Zhang, Xue, Y., Zhao, M. Y., Wang, H. J., Li, J. C., Liu, J. Y., Li, F. J., and Zhou, J. M., “Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population”, vol. 10, pp. 7-15, 2011.

Toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP; also known as MAL) is an essential adaptor molecule in Toll-like receptor signaling, involved in activating the innate immune response during infection. Genetic variations in the TIRAP gene may influence human susceptibility to infectious disease. To date, in the Chinese population, a possible predisposition of TIRAP gene variants to tuberculosis has not been reported.

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