Tumor

NF1 frameshift mutation (c.6520_6523delGAGA) association with nervous system tumors and bone abnormalities in a Chinese patient with neurofibromatosis type 1

S. Y. Su, Zhou, X., Pang, X. M., Chen, C. Y., Li, S. H., Liu, J. L., Su, S. Y., Zhou, X., Pang, X. M., Chen, C. Y., Li, S. H., Liu, J. L., Su, S. Y., Zhou, X., Pang, X. M., Chen, C. Y., Li, S. H., and Liu, J. L., NF1 frameshift mutation (c.6520_6523delGAGA) association with nervous system tumors and bone abnormalities in a Chinese patient with neurofibromatosis type 1, vol. 15, p. -, 2016.

Neurofibromatosis type 1, also known as NF1 or von Recklinghausen’s disease, is a common neurocutaneous syndrome that presents with multiple café-au-lait patches, skinfold freckling, dermatofibromas, neurofibromas, and Lisch nodules. The mutations of the gene NF1, encoding the protein neurofibromin, have been identified as the cause of this disease. Here, we report a clinical and molecular study of a Chinese patient with multiple café-au-lait skin freckles, dermatofibroma, central and peripheral nervous system tumors, and bone abnormalities attributed to NF1.

O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines

G. G. Nde S. Wisintainer, Scola, G., Moura, S., Lemos, T. L. G., Pessoa, C., de Moraes, M. O., Souza, L. G. S., Roesch-Ely, M., and Henriques, J. A. P., O-naphthoquinone isolated from Capraria biflora L. induces selective cytotoxicity in tumor cell lines, vol. 14, pp. 17472-17481, 2015.

Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analysis. The cytotoxicity was further evaluated exclusively for 48 h of treatment in different tumor and non-tumor cell lines (Hep-2, HeLa, HT-29, A-375, and A-549, and HEK-293, respectively). The results indicated that biflorin induced selective cytotoxicity in tumor cells.

Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy

H. Lu, Lan, W. X., Bo, L., Niu, C., Zhou, J. J., and Zhu, H. L., Metabolic response of LLC xenografted mice to oxythiamine, as measured by [1H] NMR spectroscopy, vol. 14, pp. 11043-11051, 2015.

Oxythiamine (OT) has been proven to be a potential anticancer drug. With the help of NMR-based metabonomics, we studied the metabolic changes within tumor-bearing mice with different levels of OT administration using a C57BL/6 mouse Lewis lung carcinoma tumor transplantation model. We administered different concentrations of OT (75, 150, 300, and 600 mg∙kg-1∙day-1) to the mice orally for 2 weeks, recorded animal weights and tumor volumes, sacrificed the animals, and collected blood and tumor mass samples for nuclear magnetic resonance determination.

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