Tumor necrosis factor-related apoptosis-inducing ligand

Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population

M. Y. Yu, Zhao, P. Q., Yan, X. H., Liu, B., Zhang, Q. Q., Wang, R., Ma, C. H., Liang, X. H., Zhu, F. L., and Gao, L. F., Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population, vol. 12, pp. 3455-3464, 2013.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM).

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