Type 2 diabetes

Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy

C. - H. Hsieh, Pei, D., Hung, Y. - J., and Hsiao, F. - C., Association between retinoid-X receptor-gamma genetic polymorphisms and diabetic retinopathy, vol. 10, pp. 3545-3551, 2011.

Retinoid-X receptor (RXR) is one of the members of the nuclear hormone receptor superfamily. It forms heterodimers with many nuclear receptors, such as the peroxisome proliferative-activated receptor, which has been proposed to be involved in diabetic complications, including retinopathy. A recent study revealed that RXR-alpha has antioxidant properties and is associated with diabetic retinopathy. We found that the RXR-gamma gene is involved in the pathogenesis of diabetic nephropathy.

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