UGT1A1

Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women

J. Shi, Li, L. H., Duan, X. Y., Liu, Q., Sun, L. L., Tian, Y. T., Shi, J., Li, L. H., Duan, X. Y., Liu, Q., Sun, L. L., and Tian, Y. T., Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women, vol. 15, p. -, 2016.

Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymorphisms have been identified in the UGT1A1 locus. UGT1A1*28 has been previously linked to increased risk of breast cancer.

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