Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women
“Gly71Arg UGT1A1 polymorphism is associated with breast cancer susceptibility in Han Chinese women”, vol. 15, p. -, 2016.
, Breast cancer is among the most common causes of cancer-related death in women worldwide. Previous studies have demonstrated an association between prolonged estrogen exposure and increased risk of breast cancer. Uridine 5'-diphospho-glucuronosyltransferase 1-1 (UGT1A1) plays a significant role in the detoxification of estrogens. Two major genetic polymorphisms have been identified in the UGT1A1 locus. UGT1A1*28 has been previously linked to increased risk of breast cancer.