Vaccine

 Prevalence and genotype distribution of human papillomavirus in women in the Henan Province

Y. - F. Zhi, Cha, X. - X., Li, X. - F., Qiu, C., and Rong, S. - H., “ Prevalence and genotype distribution of human papillomavirus in women in the Henan Province”, vol. 14, pp. 5452-5461, 2015.

We studied human papillomavirus (HPV) prevalence and genotype distribution among women in the Henan Province to provide epidemiological data as a means of preventing cervical cancer and developing a vaccine. A total of 14,873 samples were genotyped by using polymerase chain reaction reverse dot-blot. The overall HPV-positive rate in the sample was 23.98% (3566/14873), of which 69.01% (2461/3566) were infected with high-risk HPV types and 17.33% (618/3566) with low-risk types.

Identification of a new Schistosoma mansoni membrane-bound protein through bioinformatic analysis

F. C. Cardoso, Pinho, J. M. R., Azevedo, V., and Oliveira, S. C., “Identification of a new Schistosoma mansoni membrane-bound protein through bioinformatic analysis”, vol. 5, pp. 609-618, 2006.

Progress in schistosome genome research has enabled investigators to move rapidly from genome sequences to vaccine development. Proteins bound to the surface of parasites are potential vaccine candidates, or they can be used for diagnosis. We analyzed 4342 proteins deduced from the Schistosoma mansoni transcriptome with bioinformatic computer programs. Thirty-four proteins had membrane-bound motifs. Within this group, we selected the Sm29 protein to be further characterized by in silico analysis.

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