Wnt/β-catenin

5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway

H. Zhang, Zhou, W. C., Li, X., Meng, W. B., Zhang, L., Zhu, X. L., Zhu, K. X., Bai, Z. T., Yan, J., Liu, T., Xu, X. C., and Li, Y. M., 5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway, vol. 13, pp. 5064-5072, 2014.

5-Azacytidine has been shown to be an effective anti-pancreatic cancer drug, but the mechanism remains unknown. In the current study, we explored the effect of 5-azacytidine on abnormal activation of the Wnt-β-catenin signaling pathway in pancreatic cancer cells. The human pancreatic cancer cell line Bxpc-3 was treated with different concentrations of 5-azacytidine for various times. The proliferation and early apoptosis of the cells were evaluated using the CCK8 method and flow cytometry, respectively.

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