Wnt/β-catenin

Expression of EpCAM and Wnt/ β-catenin in human colon cancer

F. Q. Zhou, Qi, Y. M., Xu, H., Wang, Q. Y., Gao, X. S., and Guo, H. G., Expression of EpCAM and Wnt/ β-catenin in human colon cancer, vol. 14, pp. 4485-4494, 2015.

The aims of this study were to explore the correlation between the expression of EpCAM and the Wnt/β-catenin pathway in human colon cancer and its clinical significance for the evaluation of cancer prognosis. Samples from colon cancer, para-carcinoma, or benign intestinal tissue from individual patients (50) and from normal intestinal mucosal tissues (20) were obtained from the Pathology Department of the Shandong Province Binzhou People’s Hospital (Shandong, China).

5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway

H. Zhang, Zhou, W. C., Li, X., Meng, W. B., Zhang, L., Zhu, X. L., Zhu, K. X., Bai, Z. T., Yan, J., Liu, T., Xu, X. C., and Li, Y. M., 5-Azacytidine suppresses the proliferation of pancreatic cancer cells by inhibiting the Wnt/β-catenin signaling pathway, vol. 13, pp. 5064-5072, 2014.

5-Azacytidine has been shown to be an effective anti-pancreatic cancer drug, but the mechanism remains unknown. In the current study, we explored the effect of 5-azacytidine on abnormal activation of the Wnt-β-catenin signaling pathway in pancreatic cancer cells. The human pancreatic cancer cell line Bxpc-3 was treated with different concentrations of 5-azacytidine for various times. The proliferation and early apoptosis of the cells were evaluated using the CCK8 method and flow cytometry, respectively.

Wnt/β-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1

B. Q. Cheng, Jiang, Y., Zhu, Q., and Lin, W. G., Wnt/β-catenin aids in regulating the proliferation of hepG2 cells mediated by thy-1, vol. 13, pp. 5115-5127, 2014.

Cancer stem cells have been found to play important roles in carcinoma. Although thy-1 has been identified as a potential stem cell marker of liver cancer, whether the Wnt/β-catenin signaling pathway plays an important role in regulating hepatocarcinoma proliferation and apoptosis mediated by thy-1 remains unknown. Our results showed that high thy-1 expression caused hepG2 cells transfected with a pReceiver-M29/thy-1 eukaryotic expression vector to exhibit obvious heteromorphism, featuring double or multiple nuclei and weaker apoptosis.

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