XRCC1 gene

Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population

X. F. Li, Chen, Y. X., Ye, W. W., Tao, X. F., Zhu, J. H., Wu, S., and Lou, L. Q., Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population, vol. 13, pp. 160-166, 2014.

The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls using the created restriction site-polymerase chain reaction method.

Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population

Z. M. Zhao, Li, C. G., Hu, M. G., Gao, Y. X., and Liu, R., Influence of the c.1517G>C genetic variant in the XRCC1 gene on pancreatic cancer susceptibility in a Chinese population, vol. 13, pp. 4466-4472, 2014.

We investigated the influence of the c.1517G>C genetic variant in the X-ray repair complementing group 1 gene (XRCC1) on pancreatic cancer (PC) susceptibility in Chinese patients. A total of 390 PC patients and 392 controls were enrolled in this case-control study. The genotypes of c.1517G>C genetic variants were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Our findings suggested that the allele and genotype frequencies in PC patients were significantly different from those in cancer-free controls.

MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer

R. Muñiz-Mendoza, Ayala-Madrigal, M. L., Partida-Pérez, M., Peregrina-Sandoval, J., Leal-Ugarte, E., Macias-Gomez, N., Peralta-Leal, V., Meza-Espinoza, J. P., Moreno-Ortiz, J. M., Ramírez-Ramírez, R., Suárez-Villanueva, S., and Gutierrez-Angulo, M., MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer, vol. 11, pp. 2315-2320, 2012.

DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis and 120 blood donors (control group) from Western Mexico; both groups were mestizos. The polymorphisms were detected by PCR-RFLP.

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