Y chromosome microdeletions

Pedigrees of infertile Chinese men with Y chromosome microdeletions derived from natural transmission and de novo mutation

L. L. Li, Zhu, Y. Z., Yu, X. W., Wang, R. X., Hu, Z. M., and Liu, R. Z., Pedigrees of infertile Chinese men with Y chromosome microdeletions derived from natural transmission and de novo mutation, vol. 14, pp. 1932-1941, 2015.

Y chromosome microdeletions can cause male infertility and are classified as natural transmission and de novo mutations. To examine the source of these deletions in Chinese men and to provide a theoretical and laboratory basis for genetic counseling, patients from Northeast China with primary male infertility (N = 22) and their fathers were investigated. Karyotype analysis was performed on peripheral blood lymphocytes using standard G-banding.

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