Z-Island method

Prediction of genomic islands in seven human pathogens using the Z-Island method

W. Wei and Guo, F. - B., Prediction of genomic islands in seven human pathogens using the Z-Island method, vol. 10, pp. 2307-2315, 2011.

We adopted the method of Zhang and Zhang (the Z-Island method) to identify genomic islands in seven human pathogens, analyzing their chromosomal DNA sequences. The Z-Island method is a theoretical method for predicting genomic islands in bacterial genomes; it consists of determination of the cumulative GC profile and computation of codon usage bias. Thirty-one genomic islands were found in seven pathogens using this method. Further analysis demonstrated that most have the known conserved features; this increases the probability that they are real genomic islands.

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