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“Effects of intra- and extracellular factors on anti-aging klotho gene expression”, vol. 10, pp. 2009-2023, 2011.
, Abdulamir AS, Hafidh RR, Mahdi LK, Al-jeboori TR, et al. (2008). The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma. Am. J. Immunol. 4: 14-22.
http://dx.doi.org/10.3844/ajisp.2008.14.22
Alexander RT, Woudenberg-Vrenken TE, Buurman J, Dijkman H, et al. (2009). Klotho prevents renal calcium loss. J. Am. Soc. Nephrol. 20: 2371-2379.
http://dx.doi.org/10.1681/ASN.2008121273
PMid:19713312 PMCid:2799169
Arking DE, Krebsova A, Macek M Sr, Macek M Jr, et al. (2002). Association of human aging with a functional variant of klotho. Proc. Natl. Acad. Sci. U. S. A. 99: 856-861.
http://dx.doi.org/10.1073/pnas.022484299
PMid:11792841 PMCid:117395
Arking DE, Becker DM, Yanek LR, Fallin D, et al. (2003). Klotho allele status and the risk of early-onset occult coronary artery disease. Am. J. Hum. Genet. 72: 1154-1161.
http://dx.doi.org/10.1086/375035
PMid:12669274
Bartke A (2006). Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging. Trends Endocrinol. Metab. 17: 33-35.
http://dx.doi.org/10.1016/j.tem.2006.01.002
Bjorklund P, Krajisnik T, Akerstrom G, Westin G, et al. (2008). Type I membrane klotho expression is decreased and inversely correlated to serum calcium in primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 93: 4152-4157.
http://dx.doi.org/10.1210/jc.2008-0564
de Oliveira RM (2006). Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett. 580: 5753-5758.
http://dx.doi.org/10.1016/j.febslet.2006.09.036
PMid:17014852
Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, et al. (2006). Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem. Biophys. Res. Commun. 339: 827-832.
http://dx.doi.org/10.1016/j.bbrc.2005.11.094
PMid:16325773
Imura A, Tsuji Y, Murata M, Maeda R, et al. (2007). Alpha-klotho as a regulator of calcium homeostasis. Science 316: 1615-1618.
http://dx.doi.org/10.1126/science.1135901
PMid:17569864
Kawaguchi H, Manabe N, Chikuda H, Nakamura K, et al. (2000). Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse. Cell. Mol. Life Sci. 57: 731-737.
http://dx.doi.org/10.1007/s000180050037
Koh N, Fujimori T, Nishiguchi S, Tamori A, et al. (2001). Severely reduced production of klotho in human chronic renal failure kidney. Biochem. Biophys. Res. Commun. 280: 1015-1020.
http://dx.doi.org/10.1006/bbrc.2000.4226
PMid:11162628
Kuro-o M (2006). Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr. Opin. Nephrol. Hypertens. 15: 437-441.
http://dx.doi.org/10.1097/01.mnh.0000232885.81142.83
PMid:16775459
Kuro-o M (2008). Klotho as a regulator of oxidative stress and senescence. Biol. Chem. 389: 233-241.
http://dx.doi.org/10.1515/BC.2008.028
PMid:18177265
Kuro-o M (2010). Klotho. Pflugers Arch. 459: 333-343.
http://dx.doi.org/10.1007/s00424-009-0722-7
PMid:19730882
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, et al. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
http://dx.doi.org/10.1038/36285
PMid:9363890
Kurosu H, Yamamoto M, Clark JD, Pastor JV, et al. (2005). Suppression of aging in mice by the hormone Klotho. Science 309: 1829-1833.
http://dx.doi.org/10.1126/science.1112766
PMid:16123266 PMCid:2536606
Liu Y, Sanoff HK, Cho H, Burd CE, et al. (2009). Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell 8: 439-448.
http://dx.doi.org/10.1111/j.1474-9726.2009.00489.x
PMid:19485966 PMCid:2752333
Matsumura Y, Aizawa H, Shiraki-Iida T, Nagai R, et al. (1998). Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem. Biophys. Res. Commun. 242: 626-630.
http://dx.doi.org/10.1006/bbrc.1997.8019
PMid:9464267
Melk A, Kittikowit W, Sandhu I, Halloran KM, et al. (2003). Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening. Kidney Int. 63: 2134-2143.
http://dx.doi.org/10.1046/j.1523-1755.2003.00032.x
PMid:12753300
Melk A, Schmidt BM, Takeuchi O, Sawitzki B, et al. (2004). Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int. 65: 510-520.
http://dx.doi.org/10.1111/j.1523-1755.2004.00438.x
PMid:14717921
Mori K, Yahata K, Mukoyama M, Suganami T, et al. (2000). Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem. Biophys. Res. Commun. 278: 665-670.
http://dx.doi.org/10.1006/bbrc.2000.3864
PMid:11095966
Nabeshima Y (2008). The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis. Cell. Mol. Life Sci. 65: 3218-3230.
http://dx.doi.org/10.1007/s00018-008-8177-0
PMid:18726073
Negri AL (2005). The klotho gene: a gene predominantly expressed in the kidney is a fundamental regulator of aging and calcium/phosphorus metabolism. J. Nephrol. 18: 654-658.
PMid:16358222
Niwa H, Yamamura K and Miyazaki J (1991). Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193-199.
http://dx.doi.org/10.1016/0378-1119(91)90434-D
Razzaque MS (2009). The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat. Rev. Endocrinol. 5: 611-619.
http://dx.doi.org/10.1038/nrendo.2009.196
PMid:19844248 PMCid:3107967
Serrano M, Hannon GJ and Beach D (1993). A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707.
http://dx.doi.org/10.1038/366704a0
PMid:8259215
Shiraki-Iida T, Aizawa H, Matsumura Y, Sekine S, et al. (1998). Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 424: 6-10.
http://dx.doi.org/10.1016/S0014-5793(98)00127-6
Suga T, Kurabayashi M, Sando Y, Ohyama Y, et al. (2000). Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. Am. J. Respir. Cell Mol. Biol. 22: 26-33.
PMid:10615062
Turan K and Nagata K (2006). Chitosan-DNA nanoparticles: the effect of cell type and hydrolysis of chitosan on in vitro DNA transfection. Pharm. Dev. Technol. 11: 503-512.
http://dx.doi.org/10.1080/10837450600940873
PMid:17101521
Weissman JD and Singer DS (1991). Striking similarities between the regulatory mechanisms governing yeast mating-type genes and mammalian major histocompatibility complex genes. Mol. Cell. Biol. 11: 4228-4234.
PMid:2072916 PMCid:361249
Wolf I, Levanon-Cohen S, Bose S, Ligumsky H, et al. (2008). Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene 27: 7094-7105.
http://dx.doi.org/10.1038/onc.2008.292
PMid:18762812
Yamamoto M, Clark JD, Pastor JV, Gurnani P, et al. (2005). Regulation of oxidative stress by the anti-aging hormone klotho. J. Biol. Chem. 280: 38029-38034.
http://dx.doi.org/10.1074/jbc.M509039200
PMid:16186101 PMCid:2515369