Publications

Abraham C and Cho JH (2009). IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 60: 97-110. http://dx.doi.org/10.1146/annurev.med.60.051407.123757 PMid:18976050   Baumgart DC (2008). What's new in inflammatory bowel disease in 2008? World J. Gastroenterol. 14: 329-330. http://dx.doi.org/10.3748/wjg.14.329 PMid:18200655 PMCid:2679121   Cavanaugh J (2001). International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am. J. Hum. Genet. 68: 1165-1171. http://dx.doi.org/10.1086/320119 PMid:11309682   Cho JH (2008). The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8: 458-466. http://dx.doi.org/10.1038/nri2340 PMid:18500230   Chua KH, Hilmi I, Ng CC, Eng TL, et al. (2009a). Identification of NOD2/CARD15 mutations in Malaysian patients with Crohn's disease. J. Dig. Dis. 10: 124-130. http://dx.doi.org/10.1111/j.1751-2980.2009.00374.x PMid:19426395   Chua KH, Lau TP, Yee ZY, Tan SY, et al. (2009b). Genetic polymorphisms of the IL-1 511 and +3954 single nucleotide polymorphisms (SNPs) in the Malaysian systemic lupus erythematosus (SLE) patients. J. Health Sci. 55: 657-662. http://dx.doi.org/10.1248/jhs.55.657   Chua KH, Puah SM, Chew CH, Tan SY, et al. (2010). Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia. Ann. Hum. Biol. 37: 274-280. http://dx.doi.org/10.3109/03014460903325185 PMid:19951233   Chua KH, Lian LH, Kee BP, Thum CM, et al. (2011a). Identification of DLG5 and SLC22A5 gene polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 12: 459-466. http://dx.doi.org/10.1111/j.1751-2980.2011.00533.x PMid:22118696   Chua KH, Puah SM, Chew CH, Wong CH, et al. (2011b). Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. Pancreatology 11: 441-444. http://dx.doi.org/10.1159/000330943 PMid:21952138   Chua KH, Hilmi I, Lian LH, Patmanathan SN, et al. (2012). Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 13: 459-465. http://dx.doi.org/10.1111/j.1751-2980.2012.00617.x PMid:22908971   Cunninghame Graham DS, Akil M and Vyse TJ (2007). Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. Rheumatology 46: 927-930. http://dx.doi.org/10.1093/rheumatology/kel449 PMid:17384181   David M (2002). Signal transduction by type I interferons. Biotechniques (Suppl): 58-65. PMid:12395928   Goh KL (2007). Changing trends in gastrointestinal disease in the Asia-Pacific region. J. Dig. Dis. 8: 179-185. http://dx.doi.org/10.1111/j.1751-2980.2007.00304.x PMid:17970873   Hugot JP, Chamaillard M, Zouali H, Lesage S, et al. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603. http://dx.doi.org/10.1038/35079107 PMid:11385576   Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, et al. (2009). Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. Mod. Rheumatol. 19: 401-406. http://dx.doi.org/10.1007/s10165-009-0173-1 PMid:19440814   Leong RW, Lau JY and Sung JJ (2004). The epidemiology and phenotype of Crohn's disease in the Chinese population. Inflamm. Bowel. Dis. 10: 646-651. http://dx.doi.org/10.1097/00054725-200409000-00022 PMid:15472528   Lindqvist AK, Steinsson K, Johanneson B, Kristjansdottir H, et al. (2000). A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J. Autoimmun. 14: 169-178. http://dx.doi.org/10.1006/jaut.1999.0357 PMid:10677248   Lovato P, Brender C, Agnholt J, Kelsen J, et al. (2003). Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J. Biol. Chem. 278: 16777-16781. http://dx.doi.org/10.1074/jbc.M207999200 PMid:12615922   McGovern D and Powrie F (2007). The IL23 axis plays a key role in the pathogenesis of IBD. Gut 56: 1333-1336. http://dx.doi.org/10.1136/gut.2006.115402 PMid:17872562 PMCid:2000291   Nakamura R, Shibata K, Yamada H, Shimoda K, et al. (2008). Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells. J. Immunol. 181: 2071- 2075. PMid:18641345   Ng ZX, Kuppusamy UR, Tajunisah I, Fong KC, et al. (2012). 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br. J. Ophthalmol. 96: 289-292. http://dx.doi.org/10.1136/bjophthalmol-2011-300658 PMid:22116960 PMCid:3261748   Ogura Y, Bonen DK, Inohara N, Nicolae DL, et al. (2001). A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606. http://dx.doi.org/10.1038/35079114 PMid:11385577   Ouyang Q, Tandon R, Goh KL, Ooi CJ, et al. (2005). The emergence of inflammatory bowel disease in the Asian Pacific region. Curr. Opin. Gastroenterol. 21: 408-413. PMid:15930979   Puah SM, Lian LH, Chew CH, Chua KH, et al. (2007). A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population. Lupus 16: 750-754. http://dx.doi.org/10.1177/0961203307079454 PMid:17728371   Raelson JV, Little RD, Ruether A, Fournier H, et al. (2007). Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc. Natl. Acad. Sci. U. S. A. 104: 14747- 14752. http://dx.doi.org/10.1073/pnas.0706645104 PMid:17804789 PMCid:1965486   Richter MF, Dumenil G, Uze G, Fellous M, et al. (1998). Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J. Biol. Chem. 273: 24723-24729. http://dx.doi.org/10.1074/jbc.273.38.24723 PMid:9733772   Sato K, Shiota M, Fukuda S, Iwamoto E, et al. (2009). Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population. J. Clin. Immunol. 29: 815-825. http://dx.doi.org/10.1007/s10875-009-9320-x PMid:19653082 PMCid:2788098   Sehgal PB, Levy DE and Hirano T (Editors) (2003). Signal Transducers and Activators of Transcription (STATs). In: Activation and Biology. Kluwer Academic Publishers, Dordrecht, 12. PMid:12568241   Shanahan F (2002). Crohn's disease. Lancet 359: 62-69. http://dx.doi.org/10.1016/S0140-6736(02)07284-7   Suarez-Gestal M, Calaza M, Dieguez-Gonzalez R, Perez-Pampin E, et al. (2009). Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors. Arthritis Rheum. 60: 2558-2564. http://dx.doi.org/10.1002/art.24748 PMid:19714582   Tan JAMA, Lee PC, Wee YC, Tan KL, et al. (2010). High prevalence of alpha and beta-thalassemia in the kadazandusuns in east malaysia: challenges in providing effective health care for an indigenous group. J. Biomed. Biotechnol. DOI: 10.1155/2010/706872. http://dx.doi.org/10.1155/2010/706872   Tao JH, Zou YF, Feng XL, Li J, et al. (2011). Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases. Mol. Biol. Rep. 38: 4663-4672. http://dx.doi.org/10.1007/s11033-010-0601-5 PMid:21140222   Teh CS, Chua KH and Thong KL (2010a). Simultaneous differential detection of human pathogenic and nonpathogenic Vibrio species using a multiplex PCR based on gyrB and pntA genes. J. Appl. Microbiol. 108: 1940-1945. PMid:19891709   Teh CS, Chua KH and Thong KL (2010b). Multiple-locus variable-number tandem repeat analysis of Vibrio cholerae in comparison with pulsed field gel electrophoresis and virulotyping. J Biomed. Biotechnol. 2010: 817190. http://dx.doi.org/10.1155/2010/817190 PMid:20671932 PMCid:2910556   Thong KL, Lai MY, Teh CS and Chua KH (2011). Simultaneous detection of methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa by multiplex PCR. Trop. Biomed. 28: 21-31. PMid:21602765   Uhlig HH, McKenzie BS, Hue S, Thompson C, et al. (2006). Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25: 309-318. http://dx.doi.org/10.1016/j.immuni.2006.05.017 PMid:16919486   Wang K, Zhang H, Kugathasan S, Annese V, et al. (2009). Diverse genome-wide association studies associate the IL12/ IL23 pathway with Crohn Disease. Am. J. Hum. Genet. 84: 399-405. http://dx.doi.org/10.1016/j.ajhg.2009.01.026 PMid:19249008 PMCid:2668006   Watford WT, Hissong BD, Bream JH, Kanno Y, et al. (2004). Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 202: 139-156. http://dx.doi.org/10.1111/j.0105-2896.2004.00211.x PMid:15546391   Yang SK, Loftus EV Jr and Sandborn WJ (2001). Epidemiology of inflammatory bowel disease in Asia. Inflamm. Bowel. Dis. 7: 260-270. http://dx.doi.org/10.1097/00054725-200108000-00013 PMid:11515854

Agundez JA, Jimenez-Jimenez FJ, Luengo A, Molina JA, et al. (1998). Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson's disease. Neurology 51: 1587-1592. http://dx.doi.org/10.1212/WNL.51.6.1587 PMid:9855506   Ambrosone CB, Freudenheim JL, Graham S, Marshall JR, et al. (1996). Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. JAMA 276: 1494-1501. http://dx.doi.org/10.1001/jama.1996.03540180050032 PMid:8903261   Bhowmick DA, Zhuang Z, Wait SD and Weil RJ (2004). A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. Cancer Res. 64: 1220-1223. http://dx.doi.org/10.1158/0008-5472.CAN-03-3137 PMid:14973082   Butcher NJ, Boukouvala S, Sim E and Minchin RF (2002). Pharmacogenetics of the arylamine N-acetyltransferases. Pharmacogenomics J. 2: 30-42. http://dx.doi.org/10.1038/sj.tpj.6500053 PMid:11990379   Cascorbi I, Drakoulis N, Brockmoller J, Maurer A, et al. (1995). Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am. J. Hum. Genet. 57: 581-592. PMid:7668286 PMCid:1801274   Chua KH, Kee BP, Tan SY and Lian LH (2009a). Interleukin-6 promoter polymorphisms (-174 G/C) in Malaysian patients with systemic lupus erythematosus. Braz. J. Med. Biol. Res. 42: 551-555. http://dx.doi.org/10.1590/S0100-879X2009000600012 PMid:19448905   Chua KH, Lau TP, Tee ZY, Tan SY, et al. (2009b). Genetic polymorphisms of the IL-1 511 and +3954 SNPs in the Malaysian SLE patients. J. Health Sci. 55: 657-662. http://dx.doi.org/10.1248/jhs.55.657   Chua KH, Lian LH, Kee BP, Thum CM, et al. (2011a). Identification of DLG5 and SLC22A5 gene polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 12: 459-466. http://dx.doi.org/10.1111/j.1751-2980.2011.00533.x PMid:22118696   Chua KH, Puah SM, Chew CH, Wong CH, et al. (2011b). Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. Pancreatology 11: 441-444. http://dx.doi.org/10.1159/000330943 PMid:21952138   Costa BM, Ferreira P, Costa S, Canedo P, et al. (2007). Association between functional EGF+61 polymorphism and glioma risk. Clin. Cancer Res. 13: 2621-2626. http://dx.doi.org/10.1158/1078-0432.CCR-06-2606 PMid:17473192   Davis FG, Freels S, Grutsch J, Barlas S, et al. (1998). Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973-1991. J. Neurosurg. 88: 1-10. http://dx.doi.org/10.3171/jns.1998.88.1.0001 PMid:9420066   Halatsch ME, Schmidt U, Behnke-Mursch J, Unterberg A, et al. (2006). Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours. Cancer Treat. Rev. 32: 74-89. http://dx.doi.org/10.1016/j.ctrv.2006.01.003 PMid:16488082   Kleihues P and Cavanee WK (2000). Pathology and Genetics of Tumours of the Nervous System. 2nd edn. IARC Press, Lyon.   Liu Y, Shete S, Hosking FJ, Robertson LB, et al. (2010). New insights into susceptibility to glioma. Arch. Neurol. 67: 275-278. http://dx.doi.org/10.1001/archneurol.2010.4 PMid:20212223   Ng ZX, Kuppusamy UR, Tajunisah I, Fong KC, et al. (2012). 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br. J. Ophthalmol. 96: 289-292. http://dx.doi.org/10.1136/bjophthalmol-2011-300658 PMid:22116960 PMCid:3261748   Nicholson RI, Gee JM and Harper ME (2001). EGFR and cancer prognosis. Eur. J. Cancer 37 (Suppl 4): S9-15. http://dx.doi.org/10.1016/S0959-8049(01)00231-3   Olayioye MA, Neve RM, Lane HA and Hynes NE (2000). The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19: 3159-3167. http://dx.doi.org/10.1093/emboj/19.13.3159 PMid:10880430 PMCid:313958   Salomon DS, Brandt R, Ciardiello F and Normanno N (1995). Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19: 183-232. http://dx.doi.org/10.1016/1040-8428(94)00144-I   Shahbazi M, Pravica V, Nasreen N, Fakhoury H, et al. (2002). Association between functional polymorphism in EGF gene and malignant melanoma. Lancet 359: 397-401. http://dx.doi.org/10.1016/S0140-6736(02)07600-6   Thong KL, Lai MY, Teh CS and Chua KH (2011). Simultaneous detection of methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa by multiplex PCR. Trop. Biomed. 28: 21-31. PMid:21602765   von Schmiedeberg S, Fritsche E, Ronnau AC, Specker C, et al. (1999). Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosus. Adv. Exp. Med. Biol. 455: 147-152. http://dx.doi.org/10.1007/978-1-4615-4857-7_21 PMid:10599336

Bellwood P (2007). Prehistory of the Indo-Malaysian Archipelago. ANU E Press, Australia. Blessmann M, Kaifi JT, Schurr PG, Cihan A, et al. (2008). Short tandem repeat polymorphism in exon 4 of esophageal cancer related gene 2 predicts relapse of oral squamous cell carcinoma. Oral Oncol. 44: 143-147. doi:10.1016/j.oraloncology.2007.01.013 PMid:17418617 Calafell F, Shuster A, Speed WC, Kidd JR, et al. (1998). Short tandem repeat polymorphism evolution in humans. Eur. J. Hum. Genet. 6: 38-49. doi:10.1038/sj.ejhg.5200151 PMid:9781013 Divine AM, Edlund H and Allen M (2010). Forensic analysis of autosomal STR markers using pyrosequencing. Forensic Sci. Int-Gen. 4: 122-129. Lewis CM Jr (2010). Hierarchical modeling of genome-wide short tandem repeat (STR) markers infers native American prehistory. Am. J. Phys. Anthropol. 141: 281-289. PMid:19672848 Schneider S, Roessli D and Excoffier L (2000). Arlequin: A Software for Population Genetics Data Analysis. Ver. 2.000. Genetics and Biometry Laboratory, Department of Anthropology, University of Geneva, Geneva. Tereba A (1999). Tools for Analysis of Population Statistics. Profiles in DNA 2: 14-16.