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2013
V. C. Fernandes, Pereira, S. I. V., Coppede, J., Martins, J. S., Rizo, W. F., Beleboni, R. O., Marins, M., Pereira, P. S., Pereira, A. M. S., and Fachin, A. L., The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction, vol. 12, pp. 1005-1011, 2013.
Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, et al. (2011). Worldwide burden of cervical cancer in 2008. Ann. Oncol. 22: 2675-2686. http://dx.doi.org/10.1093/annonc/mdr015 PMid:21471563   Balch CM, Buzaid AC, Soong SJ, Atkins MB, et al. (2001). Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J. Clin. Oncol. 19: 3635-3648. PMid:11504745   Barry E, Alvarez JA, Scully RE, Miller TL, et al. (2007). Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management. Expert. Opin. Pharmacother. 8: 1039-1058. http://dx.doi.org/10.1517/14656566.8.8.1039 PMid:17516870   Brandão HN, David JP, Couto RD, Nascimento JAP, et al. (2010). Chemistry and pharmacology of antineoplasic chemoterapeutical derivatives from plants. Quím. Nova 33: 1359-1369. http://dx.doi.org/10.1590/S0100-40422010000600026   Cavalcanti BC, Bezerra DP, Magalhaes HI, Moraes MO, et al. (2009). Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells. J. Appl. Toxicol. 29: 560-568. http://dx.doi.org/10.1002/jat.1439 PMid:19391104   Cavalcanti BC, Ferreira JR, Moura DJ, Rosa RM, et al. (2010). Structure-mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae). Mutat. Res. 701: 153-163. http://dx.doi.org/10.1016/j.mrgentox.2010.06.010 PMid:20599626   Ferlay J, Shin HR, Bray F, Forman D, et al. (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127: 2893-2917. http://dx.doi.org/10.1002/ijc.25516 PMid:21351269   Gordaliza M (2007). Natural products as leads to anticancer drugs. Clin. Transl. Oncol. 9: 767-776. http://dx.doi.org/10.1007/s12094-007-0138-9 PMid:18158980   Grivicich I, Regner A and Rocha AB (2007). Morte celular por apoptose. Rev. Bras. Cancerol. 53: 335-343.   Hueso-Falcón I, Girón N, Velasco P, Amaro-Luis JM, et al. (2010). Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives. Bioorg. Med. Chem. 18: 1724-1735. http://dx.doi.org/10.1016/j.bmc.2009.11.064 PMid:20116261   Januario AH, Santos SL, Marcussi S, Mazzi MV, et al. (2004). Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties. Chem. Biol. Interact. 150: 243-251. http://dx.doi.org/10.1016/j.cbi.2004.09.016 PMid:15560891   Jemal A, Bray F, Center MM, Ferlay J, et al. (2011). Global cancer statistics. CA Cancer J. Clin. 61: 69-90. http://dx.doi.org/10.3322/caac.20107 PMid:21296855   Kim R, Tanabe K, Uchida Y, Emi M, et al. (2002). Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother. Pharmacol. 50: 343-352. http://dx.doi.org/10.1007/s00280-002-0522-7 PMid:12439591   Mancebo F, Hilje L, Mora GA and Salazar R (2002). Biological activity of two neem (Azadirachta indica A. Juss., Meliaceae) products on Hypsipyla grandella (Lepidoptera: Pyralidae) larvae. Crop Protect. 21: 107-112. http://dx.doi.org/10.1016/S0261-2194(01)00069-2   Mardini H and Record C (2005). Detection assessment and monitoring of hepatic fibrosis: biochemistry or biopsy? Ann. Clin. Biochem. 42: 441-447. http://dx.doi.org/10.1258/000456305774538210 PMid:16259794   Mekhail TM and Markman M (2002). Paclitaxel in cancer therapy. Expert. Opin. Pharmacother. 3: 755-766. http://dx.doi.org/10.1517/14656566.3.6.755 PMid:12036415   Mongelli E, Pomilio AB, Sanchez JB, Guerra FM, et al. (2002). ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum. Phytother. Res. 16: 387-388. http://dx.doi.org/10.1002/ptr.955 PMid:12112299   Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63. http://dx.doi.org/10.1016/0022-1759(83)90303-4   Navarro A, de las Heras B and Villar A (2000). Immunomodulating properties of the diterpene andalusol. Planta Med. 66: 289-291. http://dx.doi.org/10.1055/s-2000-8567 PMid:10821063   Newman DJ and Cragg GM (2012). Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 75: 311-335. http://dx.doi.org/10.1021/np200906s PMid:22316239   Olsson M and Zhivotovsky B (2011). Caspases and cancer. Cell Death Differ. 18: 1441-1449. http://dx.doi.org/10.1038/cdd.2011.30 PMid:21455218 PMCid:3178435   WHO (2008). Cancer. Fact sheet No. 297.   Patel S and Goyal A (2012). Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech 2: 1-15.   Paula de Oliveira A, Santin JR, Lemos M, Klein Junior LC, et al. (2011). Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae). J. Pharm. Pharmacol. 63: 1230-1237. http://dx.doi.org/10.1111/j.2042-7158.2011.01321.x PMid:21827496   Premprasert C, Tewtrakul S, Plubrukarn A and Wungsintaweekul J (2012). Anti-inflammatory activity of diterpenes from Croton stellatopilosus on LPS-induced RAW264.7 cells. J. Nat. Med. 67: 174-181. http://dx.doi.org/10.1007/s11418-012-0668-5 PMid:22529050   Ribble D, Goldstein NB, Norris DA and Shellman YG (2005). A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnol. 5: 12. http://dx.doi.org/10.1186/1472-6750-5-12 PMid:15885144 PMCid:1142306   Roberti A, La Sala D and Cinti C (2006). Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: current views and new therapeutic prospective. J. Cell Physiol. 207: 571-581. http://dx.doi.org/10.1002/jcp.20515 PMid:16250021   Rowinsky EK (1997). The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu. Rev. Med. 48: 353-374. http://dx.doi.org/10.1146/annurev.med.48.1.353 PMid:9046968   Salatino A, Salatino MLF and Negri G (2007). Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae). J. Braz. Chem. Soc. 18: 11-33. http://dx.doi.org/10.1590/S0103-50532007000100002   Sun L, Simmerling C and Ojima I (2009). Recent advances in the study of the bioactive conformation of taxol. Chem. Med. Chem. 4: 719-731. http://dx.doi.org/10.1002/cmdc.200900044 PMid:19360801 PMCid:3072276   Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, et al. (2006). Targeting multidrug resistance in cancer. Nat. Rev. Drug Discov. 5: 219-234. http://dx.doi.org/10.1038/nrd1984 PMid:16518375   Vidal V, Potterat O, Louvel S, Hamy F, et al. (2012). Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium. J. Nat. Prod. 75: 414-419.t Prod 75: 414-419.
2012
E. V. Santos, Silva, G., Cardozo, G. P., Bitencourt, T. A., França, S. C., Fachin, A. L., and Marins, M., In silico characterization of three two-component systems of Ehrlichia canis and evaluation of a natural plant-derived inhibitor, vol. 11, pp. 3576-3584, 2012.
Aguiar DM, Hagiwara MK and Labruna MB (2008). In vitro isolation and molecular characterization of an Ehrlichia canis strain from São Paulo, Brazil. Braz. J. Microbiol. 39: 489-493. http://dx.doi.org/10.1590/S1517-83822008000300014   Altschul SF, Madden TL, Schaffer AA, Zhang J, et al. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402. http://dx.doi.org/10.1093/nar/25.17.3389 PMid:9254694 PMCid:146917   Armitage JP (1992). Behavioral responses in bacteria. Annu. Rev. Physiol. 54: 683-714. http://dx.doi.org/10.1146/annurev.ph.54.030192.003343 PMid:1562188   Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, et al. (2011). GenBank. Nucleic Acids Res. 39: D32-D37. http://dx.doi.org/10.1093/nar/gkq1079 PMid:21071399 PMCid:3013681   Cheng Z, Kumagai Y, Lin M, Zhang C, et al. (2006). Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell Microbiol. 8: 1241-1252. http://dx.doi.org/10.1111/j.1462-5822.2006.00704.x PMid:16882029   Dumler JS, Barbet AF, Bekker CP, Dasch GA, et al. (2001). Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales: unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and "HGE agent" as subjective synonyms of Ehrlichia phagocytophila. Int. J. Syst. Evol. Microbiol. 51: 2145-2165. http://dx.doi.org/10.1099/00207713-51-6-2145 PMid:11760958   Finlay BB (2010). The art of bacterial warfare. Sci. Am. 302: 56-63. http://dx.doi.org/10.1038/scientificamerican0210-56 PMid:20128224   Gao R and Stock AM (2009). Biological insights from structures of two-component proteins. Ann. Rev. Microbiol. 63: 133-154. http://dx.doi.org/10.1146/annurev.micro.091208.073214 PMid:19575571   Gotoh Y, Eguchi Y, Watanabe T, Okamoto S, et al. (2010). Two-component signal transduction as potential drug targets in pathogenic bacteria. Curr. Opin. Microbiol. 13: 232-239. http://dx.doi.org/10.1016/j.mib.2010.01.008 PMid:20138000   Hecht GB, Lane T, Ohta N, Sommer JM, et al. (1995). An essential single domain response regulator required for normal cell division and differentiation in Caulobacter crescentus. EMBO J. 14: 3915-3924. PMid:7664732 PMCid:394470   Hulko M, Berndt F, Gruber M, Linder JU, et al. (2006). The HAMP domain structure implies helix rotation in transmembrane signaling. Cell 126: 929-940. http://dx.doi.org/10.1016/j.cell.2006.06.058 PMid:16959572   Ishida ML, Assumpcao MC, Machado HB, Benelli EM, et al. (2002). Identification and characterization of the two-component NtrY/NtrX regulatory system in Azospirillum brasilense. Braz. J. Med. Biol. Res. 35: 651-661. http://dx.doi.org/10.1590/S0100-879X2002000600004 PMid:12045829   Jacobs C, Ausmees N, Cordwell SJ, Shapiro L, et al. (2003). Functions of the CckA histidine kinase in Caulobacter cell cycle control. Mol. Microbiol. 47: 1279-1290. http://dx.doi.org/10.1046/j.1365-2958.2003.03379.x PMid:12603734   Kumagai Y, Cheng Z, Lin M and Rikihisa Y (2006). Biochemical activities of three pairs of Ehrlichia chaffeensis two-component regulatory system proteins involved in inhibition of lysosomal fusion. Infect. Immun. 74: 5014-5022. http://dx.doi.org/10.1128/IAI.00735-06 PMid:16926392 PMCid:1594868   Laub MT and Goulian M (2007). Specificity in two-component signal transduction pathways. Annu. Rev. Genet. 41: 121-145. http://dx.doi.org/10.1146/annurev.genet.41.042007.170548 PMid:18076326   Lavin JL, Kiil K, Resano O, Ussery DW, et al. (2007). Comparative genomic analysis of two-component regulatory proteins in Pseudomonas syringae. BMC Genomics 8: 397. http://dx.doi.org/10.1186/1471-2164-8-397 PMid:17971244 PMCid:2222644   Lin YH, Gao R, Binns AN and Lynn DG (2008). Capturing the VirA/VirG TCS of Agrobacterium tumefaciens. Adv. Exp. Med. Biol. 631: 161-177. http://dx.doi.org/10.1007/978-0-387-78885-2_11 PMid:18792688   Marchler-Bauer A, Anderson JB, Chitsaz F, Derbyshire MK, et al. (2009). CDD: specific functional annotation with the conserved domain database. Nucleic Acids Res. 37: D205-D210. http://dx.doi.org/10.1093/nar/gkn845 PMid:18984618 PMCid:2686570   Markowitz VM, Chen IM, Palaniappan K, Chu K, et al. (2010). The integrated microbial genomes system: an expanding comparative analysis resource. Nucleic Acids Res. 38: D382-D390. http://dx.doi.org/10.1093/nar/gkp887 PMid:19864254 PMCid:2808961   Martinez-Nunez C, Altamirano-Silva P, Alvarado-Guillen F, Moreno E, et al. (2010). The two-component system BvrR/ BvrS regulates the expression of the type IV secretion system VirB in Brucella abortus. J. Bacteriol. 192: 5603-5608. http://dx.doi.org/10.1128/JB.00567-10 PMid:20833814 PMCid:2953682   McClure JC, Crothers ML, Schaefer JJ, Stanley PD, et al. (2010). Efficacy of a doxycycline treatment regimen initiated during three different phases of experimental ehrlichiosis. Antimicrob. Agents Chemother. 54: 5012-5020. http://dx.doi.org/10.1128/AAC.01622-09 PMid:20921310 PMCid:2981254   Miller LD, Russell MH and Alexandre G (2009). Diversity in bacterial chemotactic responses and niche adaptation. Adv. Appl. Microbiol. 66: 53-75. http://dx.doi.org/10.1016/S0065-2164(08)00803-4   Pawlowski K, Klosse U and de Bruijn FJ (1991). Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism. Mol. Gen. Genet. 231: 124-138. http://dx.doi.org/10.1007/BF00293830 PMid:1661370   Reisenauer A, Quon K and Shapiro L (1999). The CtrA response regulator mediates temporal control of gene expression during the Caulobacter cell cycle. J. Bacteriol. 181: 2430-2439. PMid:10198005 PMCid:93667   Rikihisa Y (1991). The tribe Ehrlichieae and ehrlichial diseases. Clin. Microbiol. Rev. 4: 286-308. PMid:1889044 PMCid:358200   Rikihisa Y (2010). Molecular events involved in cellular invasion by Ehrlichia chaffeensis and Anaplasma phagocytophilum. Vet. Parasitol. 167: 155-166. http://dx.doi.org/10.1016/j.vetpar.2009.09.017 PMid:19836896 PMCid:2815030   Ryjenkov DA, Tarutina M, Moskvin OV and Gomelsky M (2005). Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain. J. Bacteriol. 187: 1792-1798. http://dx.doi.org/10.1128/JB.187.5.1792-1798.2005 PMid:15716451 PMCid:1064016   Stock AM, Robinson VL and Goudreau PN (2000). Two-component signal transduction. Annu. Rev. Biochem. 69: 183-215. http://dx.doi.org/10.1146/annurev.biochem.69.1.183 PMid:10966457   Wellman ML, Krakowka S, Jacobs RM and Kociba GJ (1988). A macrophage-monocyte cell line from a dog with malignant histiocytosis. In Vitro Cell Dev. Biol. 24: 223-229. http://dx.doi.org/10.1007/BF02623551 PMid:3350786   Yuan ZC, Edlind MP, Liu P, Saenkham P, et al. (2007). The plant signal salicylic acid shuts down expression of the vir regulon and activates quormone-quenching genes in Agrobacterium. Proc. Natl. Acad. Sci. U. S. A. 104: 11790-11795. http://dx.doi.org/10.1073/pnas.0704866104 PMid:17606909 PMCid:1905925   Zhang J, Boone L, Kocz R, Zhang C, et al. (2000). At the maize/Agrobacterium interface: natural factors limiting host transformation. Chem. Biol. 7: 611-621. http://dx.doi.org/10.1016/S1074-5521(00)00007-7
2010
D. Braganholi, Bélo, M., Bertoni, B. W., Fachin, A. L., Beleboni, R. O., and Zingaretti, S. M., Genetic variability among natural populations of Zaprionus indianus (Drosophilidae) in the States of São Paulo and Minas Gerais, Brazil, vol. 9, pp. 1504-1512, 2010.
Alves SM and Bélo M (2002). Morphometric variations in the housefly, Musca domestica (L.) with latitude. Genetica 115: 243-251. http://dx.doi.org/10.1023/A:1020685727460 PMid:12440563   Ananina G, Rohde C, David JR, Valente VL, et al. (2007). Inversion polymorphism and a new polytene chromosome map of Zaprionus indianus Gupta (1970) (Diptera: Drosophilidae). Genetica 131: 117-125. http://dx.doi.org/10.1007/s10709-006-9121-6 PMid:17136577   Castro FL and Valente VLS (2001). Zaprionus indianus is invading Drosophilid communities in the southern Brazilian city of Porto Alegre. Dros. Inf. Serv. 84: 15-17.   Cruz CD (2008). Programa GENES: Diversidade Genética. Universidade Federal de Viçosa, Viçosa.   David JR, Araripe LO, Bitner-Mathé BC, Capy P, et al. (2006). Quantitative trait analysis and geographic variability of natural populations of Zaprionus indianus, a recent invader in Brazil. Heredity 96: 53-62. PMid:16222328   Excoffier L, Smouse PE and Quattro JM (1992). 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Colonization of Northeast Region of Brazil by the drosophilid flies Drosophila malerkotiliana and Zaprionus indianus, a new potential insect pest for Brazilian fruitculture. Dros. Inf. Serv. 86: 92-95.   Silva NM, Fantinel CC, Valente VLS and Valiati VH (2005). Population dynamics of the invasive species Zaprionus indianus (Gupta) (Diptera: Drosophilidae) in communities of drosophilids of Porto Alegre City, Southern of Brazil. Neotrop. Entomol. 34: 363-374. http://dx.doi.org/10.1590/S1519-566X2005000300002   Stein CP, Teixeira EP and Novo JPS (2003). Aspectos biológicos da mosca do figo, Zaprionus indianus Gupta, 1970 (Diptera: Drosophilidae). Entomotropica 18: 219-221.   Tidon R, Leite DF and Leão BFD (2003). Impact of the colonisation of Zaprionus (Diptera, Drosophilidae) in different ecosystems of the Neotropical Region: 2 years after the invasion. Biol. Conserv. 112: 299-305. http://dx.doi.org/10.1016/S0006-3207(02)00322-1   Vilela CR, Teixeira EP and Stein CP (1999). Nova praga nos figos: Zaprionus indianus Gupta, 1970. Inf. Soc. Entomol. Bras. 24: 2.   Yassin A, Capy P, Madi-Ravazzi L, Ogereau D, et al. (2008). DNA barcode discovers two cryptic species and two geographical radiations in the invasive drosophilid Zaprionus indianus. Mol. Ecol. Resour. 8: 491-501. http://dx.doi.org/10.1111/j.1471-8286.2007.02020.x PMid:21585826   Yassin A, Borai F, Capy P, David JR, et al. (2009). Evolutionary genetics of Zaprionus. II. Mitochondrial DNA and chromosomal variation of the invasive drosophilid Zaprionus indianus in Egypt. Mitochondrial DNA 20: 34-40. PMid:19444699   Yeh FC, Yang R-C and Boyle T (1999). POPGENE Version 1.31. Microsoft Window-based Freeware for Population Genetic Analysis. Quick User Guide. University of Albert, Centre for International Forestry Research. Available at [http://www.ualberta.ca/~fyeh/popgene.pdf]. Accessed February 2, 2002.