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“The epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction”, vol. 12, pp. 1005-1011, 2013.
, Arbyn M, Castellsagué X, de Sanjosé S, Bruni L, et al. (2011). Worldwide burden of cervical cancer in 2008. Ann. Oncol. 22: 2675-2686.
http://dx.doi.org/10.1093/annonc/mdr015
PMid:21471563
Balch CM, Buzaid AC, Soong SJ, Atkins MB, et al. (2001). Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J. Clin. Oncol. 19: 3635-3648.
PMid:11504745
Barry E, Alvarez JA, Scully RE, Miller TL, et al. (2007). Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management. Expert. Opin. Pharmacother. 8: 1039-1058.
http://dx.doi.org/10.1517/14656566.8.8.1039
PMid:17516870
Brandão HN, David JP, Couto RD, Nascimento JAP, et al. (2010). Chemistry and pharmacology of antineoplasic chemoterapeutical derivatives from plants. Quím. Nova 33: 1359-1369.
http://dx.doi.org/10.1590/S0100-40422010000600026
Cavalcanti BC, Bezerra DP, Magalhaes HI, Moraes MO, et al. (2009). Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells. J. Appl. Toxicol. 29: 560-568.
http://dx.doi.org/10.1002/jat.1439
PMid:19391104
Cavalcanti BC, Ferreira JR, Moura DJ, Rosa RM, et al. (2010). Structure-mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae). Mutat. Res. 701: 153-163.
http://dx.doi.org/10.1016/j.mrgentox.2010.06.010
PMid:20599626
Ferlay J, Shin HR, Bray F, Forman D, et al. (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 127: 2893-2917.
http://dx.doi.org/10.1002/ijc.25516
PMid:21351269
Gordaliza M (2007). Natural products as leads to anticancer drugs. Clin. Transl. Oncol. 9: 767-776.
http://dx.doi.org/10.1007/s12094-007-0138-9
PMid:18158980
Grivicich I, Regner A and Rocha AB (2007). Morte celular por apoptose. Rev. Bras. Cancerol. 53: 335-343.
Hueso-Falcón I, Girón N, Velasco P, Amaro-Luis JM, et al. (2010). Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives. Bioorg. Med. Chem. 18: 1724-1735.
http://dx.doi.org/10.1016/j.bmc.2009.11.064
PMid:20116261
Januario AH, Santos SL, Marcussi S, Mazzi MV, et al. (2004). Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties. Chem. Biol. Interact. 150: 243-251.
http://dx.doi.org/10.1016/j.cbi.2004.09.016
PMid:15560891
Jemal A, Bray F, Center MM, Ferlay J, et al. (2011). Global cancer statistics. CA Cancer J. Clin. 61: 69-90.
http://dx.doi.org/10.3322/caac.20107
PMid:21296855
Kim R, Tanabe K, Uchida Y, Emi M, et al. (2002). Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapy. Cancer Chemother. Pharmacol. 50: 343-352.
http://dx.doi.org/10.1007/s00280-002-0522-7
PMid:12439591
Mancebo F, Hilje L, Mora GA and Salazar R (2002). Biological activity of two neem (Azadirachta indica A. Juss., Meliaceae) products on Hypsipyla grandella (Lepidoptera: Pyralidae) larvae. Crop Protect. 21: 107-112.
http://dx.doi.org/10.1016/S0261-2194(01)00069-2
Mardini H and Record C (2005). Detection assessment and monitoring of hepatic fibrosis: biochemistry or biopsy? Ann. Clin. Biochem. 42: 441-447.
http://dx.doi.org/10.1258/000456305774538210
PMid:16259794
Mekhail TM and Markman M (2002). Paclitaxel in cancer therapy. Expert. Opin. Pharmacother. 3: 755-766.
http://dx.doi.org/10.1517/14656566.3.6.755
PMid:12036415
Mongelli E, Pomilio AB, Sanchez JB, Guerra FM, et al. (2002). ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum. Phytother. Res. 16: 387-388.
http://dx.doi.org/10.1002/ptr.955
PMid:12112299
Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63.
http://dx.doi.org/10.1016/0022-1759(83)90303-4
Navarro A, de las Heras B and Villar A (2000). Immunomodulating properties of the diterpene andalusol. Planta Med. 66: 289-291.
http://dx.doi.org/10.1055/s-2000-8567
PMid:10821063
Newman DJ and Cragg GM (2012). Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 75: 311-335.
http://dx.doi.org/10.1021/np200906s
PMid:22316239
Olsson M and Zhivotovsky B (2011). Caspases and cancer. Cell Death Differ. 18: 1441-1449.
http://dx.doi.org/10.1038/cdd.2011.30
PMid:21455218 PMCid:3178435
WHO (2008). Cancer. Fact sheet No. 297.
Patel S and Goyal A (2012). Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech 2: 1-15.
Paula de Oliveira A, Santin JR, Lemos M, Klein Junior LC, et al. (2011). Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae). J. Pharm. Pharmacol. 63: 1230-1237.
http://dx.doi.org/10.1111/j.2042-7158.2011.01321.x
PMid:21827496
Premprasert C, Tewtrakul S, Plubrukarn A and Wungsintaweekul J (2012). Anti-inflammatory activity of diterpenes from Croton stellatopilosus on LPS-induced RAW264.7 cells. J. Nat. Med. 67: 174-181.
http://dx.doi.org/10.1007/s11418-012-0668-5
PMid:22529050
Ribble D, Goldstein NB, Norris DA and Shellman YG (2005). A simple technique for quantifying apoptosis in 96-well plates. BMC Biotechnol. 5: 12.
http://dx.doi.org/10.1186/1472-6750-5-12
PMid:15885144 PMCid:1142306
Roberti A, La Sala D and Cinti C (2006). Multiple genetic and epigenetic interacting mechanisms contribute to clonally selection of drug-resistant tumors: current views and new therapeutic prospective. J. Cell Physiol. 207: 571-581.
http://dx.doi.org/10.1002/jcp.20515
PMid:16250021
Rowinsky EK (1997). The development and clinical utility of the taxane class of antimicrotubule chemotherapy agents. Annu. Rev. Med. 48: 353-374.
http://dx.doi.org/10.1146/annurev.med.48.1.353
PMid:9046968
Salatino A, Salatino MLF and Negri G (2007). Traditional uses, chemistry and pharmacology of Croton species (Euphorbiaceae). J. Braz. Chem. Soc. 18: 11-33.
http://dx.doi.org/10.1590/S0103-50532007000100002
Sun L, Simmerling C and Ojima I (2009). Recent advances in the study of the bioactive conformation of taxol. Chem. Med. Chem. 4: 719-731.
http://dx.doi.org/10.1002/cmdc.200900044
PMid:19360801 PMCid:3072276
Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, et al. (2006). Targeting multidrug resistance in cancer. Nat. Rev. Drug Discov. 5: 219-234.
http://dx.doi.org/10.1038/nrd1984
PMid:16518375
Vidal V, Potterat O, Louvel S, Hamy F, et al. (2012). Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium. J. Nat. Prod. 75: 414-419.t Prod 75: 414-419.