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“Molecular response of human cervical and lumbar nucleus pulposus cells from degenerated discs following cytokine treatment”, vol. 12, pp. 838-851, 2013.
, Adam M and Deyl Z (1984). Degenerated annulus fibrosus of the intervertebral disc contains collagen type II. Ann. Rheum. Dis. 43: 258-263.
http://dx.doi.org/10.1136/ard.43.2.258
PMid:6370152 PMCid:1001478
Antoniou J, Goudsouzian NM, Heathfield TF, Winterbottom N, et al. (1996a). The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration. Spine 21: 1153-1161.
http://dx.doi.org/10.1097/00007632-199605150-00006
PMid:8727189
Antoniou J, Steffen T, Nelson F, Winterbottom N, et al. (1996b). The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J. Clin. Invest. 98: 996-1003.
http://dx.doi.org/10.1172/JCI118884
PMid:8770872 PMCid:507515
Diefenderfer DL and Brighton CT (2000). Microvascular pericytes express aggrecan message which is regulated by BMP- 2. Biochem. Biophys. Res. Commun. 269: 172-178.
http://dx.doi.org/10.1006/bbrc.2000.2148
PMid:10694496
Evans C (2006). Potential biologic therapies for the intervertebral disc. J. Bone Joint Surg. Am. 88 (Suppl 2): 95-98.
http://dx.doi.org/10.2106/JBJS.E.01328
PMid:16595452
Fassett DR, Kurd MF and Vaccaro AR (2009). Biologic solutions for degenerative disk disease. J. Spinal Disord. Tech. 22: 297-308.
http://dx.doi.org/10.1097/BSD.0b013e31816d5f64
PMid:19494751
Fei QM, Jiang XX, Chen TY, Li J, et al. (2006). Changes with age and the effect of recombinant human BMP-2 on proteoglycan and collagen gene expression in rabbit anulus fibrosus cells. Acta Biochim. Biophys. Sin. 38: 773-779.
http://dx.doi.org/10.1111/j.1745-7270.2006.00230.x
Feuerstein M, Marcus SC and Huang GD (2004). National trends in nonoperative care for nonspecific back pain. Spine J. 4: 56-63.
http://dx.doi.org/10.1016/j.spinee.2003.08.003
PMid:14749194
Genevay S, Finckh A, Mezin F, Tessitore E, et al. (2009). Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation. Arthritis Res. Ther. 11: R169.
http://dx.doi.org/10.1186/ar2858
PMid:19906289 PMCid:3003509
Kuh SU, Zhu Y, Li J, Tsai KJ, et al. (2008). Can TGF-beta1 and rhBMP-2 act in synergy to transform bone marrow stem cells to discogenic-type cells? Acta Neurochir. 150: 1073-1079.
http://dx.doi.org/10.1007/s00701-008-0029-z
PMid:18781274
Kuh SU, Zhu Y, Li J, Tsai KJ, et al. (2009). A comparison of three cell types as potential candidates for intervertebral disc therapy: annulus fibrosus cells, chondrocytes, and bone marrow derived cells. Joint Bone Spine 76: 70-74.
http://dx.doi.org/10.1016/j.jbspin.2008.02.021
PMid:18955010
Longo UG, Ripalda P, Denaro V and Forriol F (2006). Morphologic comparison of cervical, thoracic, lumbar intervertebral discs of cynomolgus monkey (Macaca fascicularis). Eur. Spine J. 15: 1845-1851.
http://dx.doi.org/10.1007/s00586-005-0035-2
PMid:16374650 PMCid:2276588
Millward-Sadler SJ, Costello PW, Freemont AJ and Hoyland JA (2009). Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res. Ther. 11: R65.
http://dx.doi.org/10.1186/ar2693
PMid:19435506 PMCid:2714110
Park JY, Kuh SU, Park HS and Kim KS (2011). Comparative expression of matrix-associated genes and inflammatory cytokines-associated genes according to disc degeneration: analysis of living human nucleus pulposus. J. Spinal Disord. Tech 24: 352-357.
http://dx.doi.org/10.1097/BSD.0b013e3181fee4df
PMid:21150669
Peng B, Hao J, Hou S, Wu W, et al. (2006). Possible pathogenesis of painful intervertebral disc degeneration. Spine 31: 560-566.
http://dx.doi.org/10.1097/01.brs.0000201324.45537.46
PMid:16508552
Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, et al. (2001). Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine 26: 1873-1878.
http://dx.doi.org/10.1097/00007632-200109010-00011
PMid:11568697
Rutges JP, Kummer JA, Oner FC, Verbout AJ, et al. (2008). Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels. J. Pathol. 214: 523-530.
http://dx.doi.org/10.1002/path.2317
PMid:18200629
Scott JE, Bosworth TR, Cribb AM and Taylor JR (1994). The chemical morphology of age-related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposus and annulus fibrosus. J. Anat. 184: 73-82.
PMid:8157495 PMCid:1259928
Seguin CA, Pilliar RM, Roughley PJ and Kandel RA (2005). Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 30: 1940-1948.
http://dx.doi.org/10.1097/01.brs.0000176188.40263.f9
PMid:16135983
Sheikh H, Zakharian K, De La Torre RP, Facek C, et al. (2009). In vivo intervertebral disc regeneration using stem cell-derived chondroprogenitors. J. Neurosurg. Spine 10: 265-272.
http://dx.doi.org/10.3171/2008.12.SPINE0835
PMid:19320588
Sobajima S, Vadala G, Shimer A, Kim JS, et al. (2008). Feasibility of a stem cell therapy for intervertebral disc degeneration. Spine J. 8: 888-896.
http://dx.doi.org/10.1016/j.spinee.2007.09.011
PMid:18082460
Tim YS, Su KK, Li J, Soo PJ, et al. (2003). The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine 28: 1773-1780.
http://dx.doi.org/10.1097/01.BRS.0000083204.44190.34
PMid:12923462
Waddell G (1996). Low back pain: a twentieth century health care enigma. Spine 21: 2820-2825.
http://dx.doi.org/10.1097/00007632-199612150-00002
PMid:9112705
Weiler C, Nerlich AG, Bachmeier BE and Boos N (2005). Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine 30: 44-53.
PMid:15626980
Yoon ST and Patel NM (2006). Molecular therapy of the intervertebral disc. Eur. Spine J. 15 (Suppl 3): S379-S388.
http://dx.doi.org/10.1007/s00586-006-0155-3
PMid:16835736 PMCid:2335383
Yoon ST, Park JS, Kim KS, Li J, et al. (2004). ISSLS prize winner: LMP-1 upregulates intervertebral disc cell production of proteoglycans and BMPs in vitro and in vivo. Spine 29: 2603-2611.
http://dx.doi.org/10.1097/01.brs.0000146103.94600.85
PMid:15564908
Zhao CQ, Wang LM, Jiang LS and Dai LY (2007). The cell biology of intervertebral disc aging and degeneration. Ageing Res. Rev. 6: 247-261.
http://dx.doi.org/10.1016/j.arr.2007.08.001
PMid:17870673