Publications
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“Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population”, vol. 13, pp. 5555-5561, 2014.
, “NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer”, vol. 13, pp. 7079-7085, 2014.
, “Lack of association between TYK2 and STAT3 genes and Crohn’s disease in the Malaysian population”, vol. 12, pp. 167-174, 2013.
, Abraham C and Cho JH (2009). IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 60: 97-110.
http://dx.doi.org/10.1146/annurev.med.60.051407.123757
PMid:18976050
Baumgart DC (2008). What's new in inflammatory bowel disease in 2008? World J. Gastroenterol. 14: 329-330.
http://dx.doi.org/10.3748/wjg.14.329
PMid:18200655 PMCid:2679121
Cavanaugh J (2001). International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am. J. Hum. Genet. 68: 1165-1171.
http://dx.doi.org/10.1086/320119
PMid:11309682
Cho JH (2008). The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8: 458-466.
http://dx.doi.org/10.1038/nri2340
PMid:18500230
Chua KH, Hilmi I, Ng CC, Eng TL, et al. (2009a). Identification of NOD2/CARD15 mutations in Malaysian patients with Crohn's disease. J. Dig. Dis. 10: 124-130.
http://dx.doi.org/10.1111/j.1751-2980.2009.00374.x
PMid:19426395
Chua KH, Lau TP, Yee ZY, Tan SY, et al. (2009b). Genetic polymorphisms of the IL-1 511 and +3954 single nucleotide polymorphisms (SNPs) in the Malaysian systemic lupus erythematosus (SLE) patients. J. Health Sci. 55: 657-662.
http://dx.doi.org/10.1248/jhs.55.657
Chua KH, Puah SM, Chew CH, Tan SY, et al. (2010). Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia. Ann. Hum. Biol. 37: 274-280.
http://dx.doi.org/10.3109/03014460903325185
PMid:19951233
Chua KH, Lian LH, Kee BP, Thum CM, et al. (2011a). Identification of DLG5 and SLC22A5 gene polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 12: 459-466.
http://dx.doi.org/10.1111/j.1751-2980.2011.00533.x
PMid:22118696
Chua KH, Puah SM, Chew CH, Wong CH, et al. (2011b). Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. Pancreatology 11: 441-444.
http://dx.doi.org/10.1159/000330943
PMid:21952138
Chua KH, Hilmi I, Lian LH, Patmanathan SN, et al. (2012). Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 13: 459-465.
http://dx.doi.org/10.1111/j.1751-2980.2012.00617.x
PMid:22908971
Cunninghame Graham DS, Akil M and Vyse TJ (2007). Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. Rheumatology 46: 927-930.
http://dx.doi.org/10.1093/rheumatology/kel449
PMid:17384181
David M (2002). Signal transduction by type I interferons. Biotechniques (Suppl): 58-65.
PMid:12395928
Goh KL (2007). Changing trends in gastrointestinal disease in the Asia-Pacific region. J. Dig. Dis. 8: 179-185.
http://dx.doi.org/10.1111/j.1751-2980.2007.00304.x
PMid:17970873
Hugot JP, Chamaillard M, Zouali H, Lesage S, et al. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603.
http://dx.doi.org/10.1038/35079107
PMid:11385576
Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, et al. (2009). Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. Mod. Rheumatol. 19: 401-406.
http://dx.doi.org/10.1007/s10165-009-0173-1
PMid:19440814
Leong RW, Lau JY and Sung JJ (2004). The epidemiology and phenotype of Crohn's disease in the Chinese population. Inflamm. Bowel. Dis. 10: 646-651.
http://dx.doi.org/10.1097/00054725-200409000-00022
PMid:15472528
Lindqvist AK, Steinsson K, Johanneson B, Kristjansdottir H, et al. (2000). A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J. Autoimmun. 14: 169-178.
http://dx.doi.org/10.1006/jaut.1999.0357
PMid:10677248
Lovato P, Brender C, Agnholt J, Kelsen J, et al. (2003). Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J. Biol. Chem. 278: 16777-16781.
http://dx.doi.org/10.1074/jbc.M207999200
PMid:12615922
McGovern D and Powrie F (2007). The IL23 axis plays a key role in the pathogenesis of IBD. Gut 56: 1333-1336.
http://dx.doi.org/10.1136/gut.2006.115402
PMid:17872562 PMCid:2000291
Nakamura R, Shibata K, Yamada H, Shimoda K, et al. (2008). Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells. J. Immunol. 181: 2071- 2075.
PMid:18641345
Ng ZX, Kuppusamy UR, Tajunisah I, Fong KC, et al. (2012). 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br. J. Ophthalmol. 96: 289-292.
http://dx.doi.org/10.1136/bjophthalmol-2011-300658
PMid:22116960 PMCid:3261748
Ogura Y, Bonen DK, Inohara N, Nicolae DL, et al. (2001). A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606.
http://dx.doi.org/10.1038/35079114
PMid:11385577
Ouyang Q, Tandon R, Goh KL, Ooi CJ, et al. (2005). The emergence of inflammatory bowel disease in the Asian Pacific region. Curr. Opin. Gastroenterol. 21: 408-413.
PMid:15930979
Puah SM, Lian LH, Chew CH, Chua KH, et al. (2007). A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population. Lupus 16: 750-754.
http://dx.doi.org/10.1177/0961203307079454
PMid:17728371
Raelson JV, Little RD, Ruether A, Fournier H, et al. (2007). Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc. Natl. Acad. Sci. U. S. A. 104: 14747- 14752.
http://dx.doi.org/10.1073/pnas.0706645104
PMid:17804789 PMCid:1965486
Richter MF, Dumenil G, Uze G, Fellous M, et al. (1998). Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J. Biol. Chem. 273: 24723-24729.
http://dx.doi.org/10.1074/jbc.273.38.24723
PMid:9733772
Sato K, Shiota M, Fukuda S, Iwamoto E, et al. (2009). Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population. J. Clin. Immunol. 29: 815-825.
http://dx.doi.org/10.1007/s10875-009-9320-x
PMid:19653082 PMCid:2788098
Sehgal PB, Levy DE and Hirano T (Editors) (2003). Signal Transducers and Activators of Transcription (STATs). In: Activation and Biology. Kluwer Academic Publishers, Dordrecht, 12.
PMid:12568241
Shanahan F (2002). Crohn's disease. Lancet 359: 62-69.
http://dx.doi.org/10.1016/S0140-6736(02)07284-7
Suarez-Gestal M, Calaza M, Dieguez-Gonzalez R, Perez-Pampin E, et al. (2009). Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors. Arthritis Rheum. 60: 2558-2564.
http://dx.doi.org/10.1002/art.24748
PMid:19714582
Tan JAMA, Lee PC, Wee YC, Tan KL, et al. (2010). High prevalence of alpha and beta-thalassemia in the kadazandusuns in east malaysia: challenges in providing effective health care for an indigenous group. J. Biomed. Biotechnol. DOI: 10.1155/2010/706872.
http://dx.doi.org/10.1155/2010/706872
Tao JH, Zou YF, Feng XL, Li J, et al. (2011). Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases. Mol. Biol. Rep. 38: 4663-4672.
http://dx.doi.org/10.1007/s11033-010-0601-5
PMid:21140222
Teh CS, Chua KH and Thong KL (2010a). Simultaneous differential detection of human pathogenic and nonpathogenic Vibrio species using a multiplex PCR based on gyrB and pntA genes. J. Appl. Microbiol. 108: 1940-1945.
PMid:19891709
Teh CS, Chua KH and Thong KL (2010b). Multiple-locus variable-number tandem repeat analysis of Vibrio cholerae in comparison with pulsed field gel electrophoresis and virulotyping. J Biomed. Biotechnol. 2010: 817190.
http://dx.doi.org/10.1155/2010/817190
PMid:20671932 PMCid:2910556
Thong KL, Lai MY, Teh CS and Chua KH (2011). Simultaneous detection of methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa by multiplex PCR. Trop. Biomed. 28: 21-31.
PMid:21602765
Uhlig HH, McKenzie BS, Hue S, Thompson C, et al. (2006). Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25: 309-318.
http://dx.doi.org/10.1016/j.immuni.2006.05.017
PMid:16919486
Wang K, Zhang H, Kugathasan S, Annese V, et al. (2009). Diverse genome-wide association studies associate the IL12/ IL23 pathway with Crohn Disease. Am. J. Hum. Genet. 84: 399-405.
http://dx.doi.org/10.1016/j.ajhg.2009.01.026
PMid:19249008 PMCid:2668006
Watford WT, Hissong BD, Bream JH, Kanno Y, et al. (2004). Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 202: 139-156.
http://dx.doi.org/10.1111/j.0105-2896.2004.00211.x
PMid:15546391
Yang SK, Loftus EV Jr and Sandborn WJ (2001). Epidemiology of inflammatory bowel disease in Asia. Inflamm. Bowel. Dis. 7: 260-270.
http://dx.doi.org/10.1097/00054725-200108000-00013
PMid:11515854