Publications

Abraham C and Cho JH (2009). IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu. Rev. Med. 60: 97-110. http://dx.doi.org/10.1146/annurev.med.60.051407.123757 PMid:18976050   Baumgart DC (2008). What's new in inflammatory bowel disease in 2008? World J. Gastroenterol. 14: 329-330. http://dx.doi.org/10.3748/wjg.14.329 PMid:18200655 PMCid:2679121   Cavanaugh J (2001). International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am. J. Hum. Genet. 68: 1165-1171. http://dx.doi.org/10.1086/320119 PMid:11309682   Cho JH (2008). The genetics and immunopathogenesis of inflammatory bowel disease. Nat. Rev. Immunol. 8: 458-466. http://dx.doi.org/10.1038/nri2340 PMid:18500230   Chua KH, Hilmi I, Ng CC, Eng TL, et al. (2009a). Identification of NOD2/CARD15 mutations in Malaysian patients with Crohn's disease. J. Dig. Dis. 10: 124-130. http://dx.doi.org/10.1111/j.1751-2980.2009.00374.x PMid:19426395   Chua KH, Lau TP, Yee ZY, Tan SY, et al. (2009b). Genetic polymorphisms of the IL-1 511 and +3954 single nucleotide polymorphisms (SNPs) in the Malaysian systemic lupus erythematosus (SLE) patients. J. Health Sci. 55: 657-662. http://dx.doi.org/10.1248/jhs.55.657   Chua KH, Puah SM, Chew CH, Tan SY, et al. (2010). Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia. Ann. Hum. Biol. 37: 274-280. http://dx.doi.org/10.3109/03014460903325185 PMid:19951233   Chua KH, Lian LH, Kee BP, Thum CM, et al. (2011a). Identification of DLG5 and SLC22A5 gene polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 12: 459-466. http://dx.doi.org/10.1111/j.1751-2980.2011.00533.x PMid:22118696   Chua KH, Puah SM, Chew CH, Wong CH, et al. (2011b). Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. Pancreatology 11: 441-444. http://dx.doi.org/10.1159/000330943 PMid:21952138   Chua KH, Hilmi I, Lian LH, Patmanathan SN, et al. (2012). Association between inflammatory bowel disease gene 5 (IBD5) and interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 13: 459-465. http://dx.doi.org/10.1111/j.1751-2980.2012.00617.x PMid:22908971   Cunninghame Graham DS, Akil M and Vyse TJ (2007). Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families. Rheumatology 46: 927-930. http://dx.doi.org/10.1093/rheumatology/kel449 PMid:17384181   David M (2002). Signal transduction by type I interferons. Biotechniques (Suppl): 58-65. PMid:12395928   Goh KL (2007). Changing trends in gastrointestinal disease in the Asia-Pacific region. J. Dig. Dis. 8: 179-185. http://dx.doi.org/10.1111/j.1751-2980.2007.00304.x PMid:17970873   Hugot JP, Chamaillard M, Zouali H, Lesage S, et al. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603. http://dx.doi.org/10.1038/35079107 PMid:11385576   Kyogoku C, Morinobu A, Nishimura K, Sugiyama D, et al. (2009). Lack of association between tyrosine kinase 2 (TYK2) gene polymorphisms and susceptibility to SLE in a Japanese population. Mod. Rheumatol. 19: 401-406. http://dx.doi.org/10.1007/s10165-009-0173-1 PMid:19440814   Leong RW, Lau JY and Sung JJ (2004). The epidemiology and phenotype of Crohn's disease in the Chinese population. Inflamm. Bowel. Dis. 10: 646-651. http://dx.doi.org/10.1097/00054725-200409000-00022 PMid:15472528   Lindqvist AK, Steinsson K, Johanneson B, Kristjansdottir H, et al. (2000). A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J. Autoimmun. 14: 169-178. http://dx.doi.org/10.1006/jaut.1999.0357 PMid:10677248   Lovato P, Brender C, Agnholt J, Kelsen J, et al. (2003). Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease. J. Biol. Chem. 278: 16777-16781. http://dx.doi.org/10.1074/jbc.M207999200 PMid:12615922   McGovern D and Powrie F (2007). The IL23 axis plays a key role in the pathogenesis of IBD. Gut 56: 1333-1336. http://dx.doi.org/10.1136/gut.2006.115402 PMid:17872562 PMCid:2000291   Nakamura R, Shibata K, Yamada H, Shimoda K, et al. (2008). Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells. J. Immunol. 181: 2071- 2075. PMid:18641345   Ng ZX, Kuppusamy UR, Tajunisah I, Fong KC, et al. (2012). 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br. J. Ophthalmol. 96: 289-292. http://dx.doi.org/10.1136/bjophthalmol-2011-300658 PMid:22116960 PMCid:3261748   Ogura Y, Bonen DK, Inohara N, Nicolae DL, et al. (2001). A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606. http://dx.doi.org/10.1038/35079114 PMid:11385577   Ouyang Q, Tandon R, Goh KL, Ooi CJ, et al. (2005). The emergence of inflammatory bowel disease in the Asian Pacific region. Curr. Opin. Gastroenterol. 21: 408-413. PMid:15930979   Puah SM, Lian LH, Chew CH, Chua KH, et al. (2007). A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population. Lupus 16: 750-754. http://dx.doi.org/10.1177/0961203307079454 PMid:17728371   Raelson JV, Little RD, Ruether A, Fournier H, et al. (2007). Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc. Natl. Acad. Sci. U. S. A. 104: 14747- 14752. http://dx.doi.org/10.1073/pnas.0706645104 PMid:17804789 PMCid:1965486   Richter MF, Dumenil G, Uze G, Fellous M, et al. (1998). Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J. Biol. Chem. 273: 24723-24729. http://dx.doi.org/10.1074/jbc.273.38.24723 PMid:9733772   Sato K, Shiota M, Fukuda S, Iwamoto E, et al. (2009). Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population. J. Clin. Immunol. 29: 815-825. http://dx.doi.org/10.1007/s10875-009-9320-x PMid:19653082 PMCid:2788098   Sehgal PB, Levy DE and Hirano T (Editors) (2003). Signal Transducers and Activators of Transcription (STATs). In: Activation and Biology. Kluwer Academic Publishers, Dordrecht, 12. PMid:12568241   Shanahan F (2002). Crohn's disease. Lancet 359: 62-69. http://dx.doi.org/10.1016/S0140-6736(02)07284-7   Suarez-Gestal M, Calaza M, Dieguez-Gonzalez R, Perez-Pampin E, et al. (2009). Rheumatoid arthritis does not share most of the newly identified systemic lupus erythematosus genetic factors. Arthritis Rheum. 60: 2558-2564. http://dx.doi.org/10.1002/art.24748 PMid:19714582   Tan JAMA, Lee PC, Wee YC, Tan KL, et al. (2010). High prevalence of alpha and beta-thalassemia in the kadazandusuns in east malaysia: challenges in providing effective health care for an indigenous group. J. Biomed. Biotechnol. DOI: 10.1155/2010/706872. http://dx.doi.org/10.1155/2010/706872   Tao JH, Zou YF, Feng XL, Li J, et al. (2011). Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases. Mol. Biol. Rep. 38: 4663-4672. http://dx.doi.org/10.1007/s11033-010-0601-5 PMid:21140222   Teh CS, Chua KH and Thong KL (2010a). Simultaneous differential detection of human pathogenic and nonpathogenic Vibrio species using a multiplex PCR based on gyrB and pntA genes. J. Appl. Microbiol. 108: 1940-1945. PMid:19891709   Teh CS, Chua KH and Thong KL (2010b). Multiple-locus variable-number tandem repeat analysis of Vibrio cholerae in comparison with pulsed field gel electrophoresis and virulotyping. J Biomed. Biotechnol. 2010: 817190. http://dx.doi.org/10.1155/2010/817190 PMid:20671932 PMCid:2910556   Thong KL, Lai MY, Teh CS and Chua KH (2011). Simultaneous detection of methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa by multiplex PCR. Trop. Biomed. 28: 21-31. PMid:21602765   Uhlig HH, McKenzie BS, Hue S, Thompson C, et al. (2006). Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25: 309-318. http://dx.doi.org/10.1016/j.immuni.2006.05.017 PMid:16919486   Wang K, Zhang H, Kugathasan S, Annese V, et al. (2009). Diverse genome-wide association studies associate the IL12/ IL23 pathway with Crohn Disease. Am. J. Hum. Genet. 84: 399-405. http://dx.doi.org/10.1016/j.ajhg.2009.01.026 PMid:19249008 PMCid:2668006   Watford WT, Hissong BD, Bream JH, Kanno Y, et al. (2004). Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol. Rev. 202: 139-156. http://dx.doi.org/10.1111/j.0105-2896.2004.00211.x PMid:15546391   Yang SK, Loftus EV Jr and Sandborn WJ (2001). Epidemiology of inflammatory bowel disease in Asia. Inflamm. Bowel. Dis. 7: 260-270. http://dx.doi.org/10.1097/00054725-200108000-00013 PMid:11515854

Bennett RA, Rubin PH and Present DH (1991). Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease. Gastroenterology 100: 1638-1643. PMid:2019369   Chan KG, Puthucheary SD, Chan XY, Yin WF, et al. (2011). Quorum sensing in Aeromonas species isolated from patients in Malaysia. Curr. Microbiol. 62: 167-172. http://dx.doi.org/10.1007/s00284-010-9689-z PMid:20544198   Chua KH, Hilmi I, Ng CC, Eng TL, et al. (2009). Identification of NOD2/CARD15 mutations in Malaysian patients with Crohn's disease. J. Dig. Dis. 10: 124-130. http://dx.doi.org/10.1111/j.1751-2980.2009.00374.x PMid:19426395   Chua KH, Lian LH, Kee BP, Thum CM, et al. (2011a). Identification of DLG5 and SLC22A5 gene polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. 12: 459-466. http://dx.doi.org/10.1111/j.1751-2980.2011.00533.x PMid:22118696   Chua KH, Puah SM, Chew CH, Wong CH, et al. (2011b). Interaction between a novel intronic IVS3+172 variant and N29I mutation in PRSS1 gene is associated with pancreatitis in a Malaysian Chinese family. Pancreatology 11: 441-444. http://dx.doi.org/10.1159/000330943 PMid:21952138   Chua KH, Hilmi I, Lian LH, Patmanathan SN, et al. (2012). Association of the inflammatory bowel disease (IBD5) and Interleukin-23 receptor (IL23R) genetic polymorphisms in Malaysian patients with Crohn's disease. J. Dig. Dis. (In Press). http://dx.doi.org/10.1111/j.1751-2980.2012.00617.x PMid:22908971   Fielding JF (1986). The relative risk of inflammatory bowel disease among parents and siblings of Crohn's disease patients. J. Clin. Gastroenterol. 8: 655-657. http://dx.doi.org/10.1097/00004836-198612000-00013 PMid:3805664   Hugot JP, Chamaillard M, Zouali H, Lesage S, et al. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411: 599-603. http://dx.doi.org/10.1038/35079107 PMid:11385576   Lesage S, Zouali H, Cezard JP, Colombel JF, et al. (2002). CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am. J. Hum. Genet. 70: 845-857. http://dx.doi.org/10.1086/339432 PMid:11875755 PMCid:379113   Moum B, Vatn MH, Ekbom A, Aadland E, et al. (1996). Incidence of Crohn's disease in four counties in southeastern Norway, 1990-93. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand. J. Gastroenterol. 31: 355-361.   Ng ZX, Kuppusamy UR, Poh R, Tajunisah I, et al. (2012a). Lack of association between Gly82Ser, 1704G/T and 2184A/G of RAGE gene polymorphisms and retinopathy susceptibility in Malaysian diabetic patients. Genet. Mol. Res. 11: 455-461. http://dx.doi.org/10.4238/2012.March.1.2 PMid:22427038   Ng ZX, Kuppusamy UR, Tajunisah I, Fong KC, et al. (2012b). 2245G/A polymorphism of the receptor for advanced glycation end-products (RAGE) gene is associated with diabetic retinopathy in the Malaysian population. Br. J. Ophthalmol. 96: 289-292. http://dx.doi.org/10.1136/bjophthalmol-2011-300658 PMid:22116960 PMCid:3261748   Ogura Y, Bonen DK, Inohara N, Nicolae DL, et al. (2001). A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411: 603-606. http://dx.doi.org/10.1038/35079114 PMid:11385577   Podolsky DK (1991a). Inflammatory bowel disease (Part I). N. Engl. J. Med. 325: 928-937. http://dx.doi.org/10.1056/NEJM199109263251306 PMid:1881418   Podolsky DK (1991b). Inflammatory bowel disease (Part II). N. Engl. J. Med. 325: 1008-1016. http://dx.doi.org/10.1056/NEJM199110033251406 PMid:1886623   Podolsky DK (2002). Inflammatory bowel disease. N. Engl. J. Med. 346: 417-429. http://dx.doi.org/10.1056/NEJMra020831 PMid:12167685   Polito JM, Childs B, Mellits ED, Tokayer AZ, et al. (1996). Crohn's disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology 111: 580-586. http://dx.doi.org/10.1053/gast.1996.v111.pm8780560 PMid:8780560   Puah SM, Lian LH, Chew CH, Chua KH, et al. (2007). A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population. Lupus 16: 750-754. http://dx.doi.org/10.1177/0961203307079454 PMid:17728371   Russell RK, Nimmo ER and Satsangi J (2004). Molecular genetics of Crohn's disease. Curr. Opin Genet. Dev. 14: 264-270. http://dx.doi.org/10.1016/j.gde.2004.04.004 PMid:15172669   Shivananda S, Lennard-Jones J, Logan R, Fear N, et al. (1996). Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut 39: 690-697. http://dx.doi.org/10.1136/gut.39.5.690 PMid:9014768 PMCid:1383393   Sugimura K, Taylor KD, Lin YC, Hang T, et al. (2003). A novel NOD2/CARD15 haplotype conferring risk for Crohn disease in Ashkenazi Jews. Am. J. Hum. Genet. 72: 509-518. http://dx.doi.org/10.1086/367848 PMid:12577202 PMCid:1180227   Tan JAMA, Lee PC, Wee YC, Tan KL, et al. (2010). High prevalence of alpha- and beta-thalassemia in the Kadazandusuns in East Malaysia: challenges in providing effective health care for an indigenous group. J. Biomed. Biotechnol. DOI 10.1155/2010/706872. http://dx.doi.org/10.1155/2010/706872   Teh CSJ, Thong KL and Chua KH (2010). Multiple-locus variable number tandem repeat analysis of Vibrio cholerae in comparison with pulsed field gel electrophoresis and virulotyping. J. Biomed. Biotechnol. DOI 10.1155/2010/817190. http://dx.doi.org/10.1155/2010/817190   Thong KL, Lai MY, Teh CS and Chua KH (2011). Simultaneous detection of methicillin-resistant Staphylococcus aureus, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa by multiplex PCR. Trop. Biomed. 28: 21-31. PMid:21602765   Tysk C, Lindberg E, Jarnerot G and Floderus-Myrhed B (1988). Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 29: 990-996. http://dx.doi.org/10.1136/gut.29.7.990 PMid:3396969 PMCid:1433769   Vermeire S, Wild G, Kocher K, Cousineau J, et al. (2002). CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Am. J. Hum. Genet. 71: 74-83. http://dx.doi.org/10.1086/341124 PMid:12019468 PMCid:384994   Vermeire S, Rutgeerts P, Van Steen K, Joossens S, et al. (2004). Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. Gut 53: 980-986. http://dx.doi.org/10.1136/gut.2003.034033 PMid:15194648 PMCid:1774099