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2016
J. L. Zheng, Li, B. S., Cao, X. C., Zhuo, W. K., Zhang, G., Zheng, J. L., Li, B. S., Cao, X. C., Zhuo, W. K., and Zhang, G., Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression, vol. 15, p. -, 2016.
J. L. Zheng, Li, B. S., Cao, X. C., Zhuo, W. K., Zhang, G., Zheng, J. L., Li, B. S., Cao, X. C., Zhuo, W. K., and Zhang, G., Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression, vol. 15, p. -, 2016.
Y. He, Jian, C. X., Zhang, H. Y., Zhou, Y., Wu, X., Zhang, G., Tan, Y. H., He, Y., Jian, C. X., Zhang, H. Y., Zhou, Y., Wu, X., Zhang, G., and Tan, Y. H., Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway, vol. 15, no. 4, p. -, 2016.
Conflicts of interest The authors declare no conflict of interest. ACKNOWLEDGMENTS We thank the anonymous reviewers for reviewing this manuscript. REFERENCES Amemiya H, Matsuzaka K, Kokubu E, Ohta S, et al (2008). Cellular responses of rat periodontal ligament cells under hypoxia and re-oxygenation conditions in vitro. J. Periodontal Res. 43: 322-327. http://dx.doi.org/10.1111/j.1600-0765.2007.01032.x Bernet JD, Doles JD, Hall JK, Kelly Tanaka K, et al (2014). p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat. Med. 20: 265-271. http://dx.doi.org/10.1038/nm.3465 Corbet EF, et al (2006). Periodontal diseases in Asians. J. Int. Acad. Periodontol. 8: 136-144. Dumitrescu AL, et al (2016). Editorial: Periodontal Disease - A Public Health Problem. Front. Public Health 3: 278. http://dx.doi.org/10.3389/fpubh.2015.00278 Eke PI, Dye BA, Wei L, Slade GD, et al (2015). Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J. Periodontol. 86: 611-622. http://dx.doi.org/10.1902/jop.2015.140520 Gay IC, Chen S, MacDougall M, et al (2007). Isolation and characterization of multipotent human periodontal ligament stem cells. Orthod. Craniofac. Res. 10: 149-160. http://dx.doi.org/10.1111/j.1601-6343.2007.00399.x Hackett PH, Roach RC, et al (2001). High-altitude illness. N. Engl. J. Med. 345: 107-114. http://dx.doi.org/10.1056/NEJM200107123450206 Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, et al (2000). Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J. Biol. Chem. 275: 9645-9652. http://dx.doi.org/10.1074/jbc.275.13.9645 Jian C, Li C, Ren Y, He Y, et al (2014). Hypoxia augments lipopolysaccharide-induced cytokine expression in periodontal ligament cells. Inflammation 37: 1413-1423. http://dx.doi.org/10.1007/s10753-014-9865-6 Li Q, Yu B, Yang P, et al (2015). Hypoxia-induced HMGB1 in would tissues promotes the osteoblast cell proliferation via activating ERK/JNK signaling. Int. J. Clin. Exp. Med. 8: 15087-15097. Liu Q, Cen L, Zhou H, Yin S, et al (2009). The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone. Tissue Eng. Part A 15: 3487-3497. http://dx.doi.org/10.1089/ten.tea.2009.0175 Matsuda N, Morita N, Matsuda K, Watanabe M, et al (1998). Proliferation and differentiation of human osteoblastic cells associated with differential activation of MAP kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro. Biochem. Biophys. Res. Commun. 249: 350-354. http://dx.doi.org/10.1006/bbrc.1998.9151 Mattioli-Belmonte M, Teti G, Salvatore V, Focaroli S, et al (2015). Stem cell origin differently affects bone tissue engineering strategies. Front. Physiol. 6: 266. http://dx.doi.org/10.3389/fphys.2015.00266 Park SY, Kim KH, Gwak EH, Rhee SH, et al (2015). Ex vivo bone morphogenetic protein 2 gene delivery using periodontal ligament stem cells for enhanced re-osseointegration in the regenerative treatment of peri-implantitis. J. Biomed. Mater. Res. A 103: 38-47. http://dx.doi.org/10.1002/jbm.a.35145 Qiu X, Zheng M, Song D, Huang L, et al (2016). Notoginsenoside Rb1 inhibits activation of ERK and p38 MAPK pathways induced by hypoxia and hypercapnia. Exp. Ther. Med. 11: 2455-2461. Rodríguez-Carballo E, Gámez B, Ventura F, et al (2016). p38 MAPK Signaling in Osteoblast Differentiation. Front. Cell Dev. Biol. 4: 40. http://dx.doi.org/10.3389/fcell.2016.00040 Seo BM, Miura M, Gronthos S, Bartold PM, et al (2004). Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155. http://dx.doi.org/10.1016/S0140-6736(04)16627-0 Somerman MJ, Young MF, Foster RA, Moehring JM, et al (1990). Characteristics of human periodontal ligament cells in vitro. Arch. Oral Biol. 35: 241-247. http://dx.doi.org/10.1016/0003-9969(90)90062-F Sun Y, Liu WZ, Liu T, Feng X, et al (2015). Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J. Recept. Signal Transduct. Res. 35: 600-604. http://dx.doi.org/10.3109/10799893.2015.1030412 Tang R, Wei F, Wei L, Wang S, et al (2014). Osteogenic differentiated periodontal ligament stem cells maintain their immunomodulatory capacity. J. Tissue Eng. Regen. Med. 8: 226-232. http://dx.doi.org/10.1002/term.1516 Terrizzi AR, Fernandez-Solari J, Lee CM, Bozzini C, et al (2013). Alveolar bone loss associated to periodontal disease in lead intoxicated rats under environmental hypoxia. Arch. Oral Biol. 58: 1407-1414. http://dx.doi.org/10.1016/j.archoralbio.2013.06.010 Trubiani O, Giacoppo S, Ballerini P, Diomede F, et al (2016). Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis. Stem Cell Res. Ther. 7: 1. http://dx.doi.org/10.1186/s13287-015-0253-4 Vandana KL, Desai R, Dalvi PJ, et al (2015). Autologous Stem Cell Application in Periodontal Regeneration Technique (SAI-PRT) Using PDLSCs Directly From an Extracted Tooth···An Insight. Int. J. Stem Cells 8: 235-237. http://dx.doi.org/10.15283/ijsc.2015.8.2.235 Wang Z, Wang W, Xu S, Wang S, et al (2016). The role of MAPK signaling pathway in the Her-2-positive meningiomas. Oncol. Rep. 36: 685-695. Wu RX, Bi CS, Yu Y, Zhang LL, et al (2015). Age-related decline in the matrix contents and functional properties of human periodontal ligament stem cell sheets. Acta Biomater. 22: 70-82. http://dx.doi.org/10.1016/j.actbio.2015.04.024 Wu Y, Yang Y, Yang P, Gu Y, et al (2013). The osteogenic differentiation of PDLSCs is mediated through MEK/ERK and p38 MAPK signalling under hypoxia. Arch. Oral Biol. 58: 1357-1368. http://dx.doi.org/10.1016/j.archoralbio.2013.03.011 Xiao X, Li Y, Zhang G, Gao Y, et al (2012). Detection of bacterial diversity in rat’s periodontitis model under imitational altitude hypoxia environment. Arch. Oral Biol. 57: 23-29. http://dx.doi.org/10.1016/j.archoralbio.2011.07.005 Xu CL, Zheng B, Pei JH, Shen SJ, et al (2016). Embelin induces apoptosis of human gastric carcinoma through inhibition of p38 MAPK and NF-κB signaling pathways. Mol. Med. Rep. 14: 307-312. Yang ZH, Zhang XJ, Dang NN, Ma ZF, et al (2009). Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissues. J. Periodontal Res. 44: 199-210. http://dx.doi.org/10.1111/j.1600-0765.2008.01106.x Zhang HY, Liu R, Xing YJ, Xu P, et al (2013). Effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts in vitro. Exp. Ther. Med. 6: 1553-1559. Zhang QB, Zhang ZQ, Fang SL, Liu YR, et al (2014). Effects of hypoxia on proliferation and osteogenic differentiation of periodontal ligament stem cells: an in vitro and in vivo study. Genet. Mol. Res. 13: 10204-10214. http://dx.doi.org/10.4238/2014.December.4.15
Y. He, Jian, C. X., Zhang, H. Y., Zhou, Y., Wu, X., Zhang, G., Tan, Y. H., He, Y., Jian, C. X., Zhang, H. Y., Zhou, Y., Wu, X., Zhang, G., and Tan, Y. H., Hypoxia enhances periodontal ligament stem cell proliferation via the MAPK signaling pathway, vol. 15, no. 4, p. -, 2016.
Conflicts of interest The authors declare no conflict of interest. ACKNOWLEDGMENTS We thank the anonymous reviewers for reviewing this manuscript. REFERENCES Amemiya H, Matsuzaka K, Kokubu E, Ohta S, et al (2008). Cellular responses of rat periodontal ligament cells under hypoxia and re-oxygenation conditions in vitro. J. Periodontal Res. 43: 322-327. http://dx.doi.org/10.1111/j.1600-0765.2007.01032.x Bernet JD, Doles JD, Hall JK, Kelly Tanaka K, et al (2014). p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat. Med. 20: 265-271. http://dx.doi.org/10.1038/nm.3465 Corbet EF, et al (2006). Periodontal diseases in Asians. J. Int. Acad. Periodontol. 8: 136-144. Dumitrescu AL, et al (2016). Editorial: Periodontal Disease - A Public Health Problem. Front. Public Health 3: 278. http://dx.doi.org/10.3389/fpubh.2015.00278 Eke PI, Dye BA, Wei L, Slade GD, et al (2015). Update on prevalence of periodontitis in adults in the United States: NHANES 2009 to 2012. J. Periodontol. 86: 611-622. http://dx.doi.org/10.1902/jop.2015.140520 Gay IC, Chen S, MacDougall M, et al (2007). Isolation and characterization of multipotent human periodontal ligament stem cells. Orthod. Craniofac. Res. 10: 149-160. http://dx.doi.org/10.1111/j.1601-6343.2007.00399.x Hackett PH, Roach RC, et al (2001). High-altitude illness. N. Engl. J. Med. 345: 107-114. http://dx.doi.org/10.1056/NEJM200107123450206 Jaiswal RK, Jaiswal N, Bruder SP, Mbalaviele G, et al (2000). Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase. J. Biol. Chem. 275: 9645-9652. http://dx.doi.org/10.1074/jbc.275.13.9645 Jian C, Li C, Ren Y, He Y, et al (2014). Hypoxia augments lipopolysaccharide-induced cytokine expression in periodontal ligament cells. Inflammation 37: 1413-1423. http://dx.doi.org/10.1007/s10753-014-9865-6 Li Q, Yu B, Yang P, et al (2015). Hypoxia-induced HMGB1 in would tissues promotes the osteoblast cell proliferation via activating ERK/JNK signaling. Int. J. Clin. Exp. Med. 8: 15087-15097. Liu Q, Cen L, Zhou H, Yin S, et al (2009). The role of the extracellular signal-related kinase signaling pathway in osteogenic differentiation of human adipose-derived stem cells and in adipogenic transition initiated by dexamethasone. Tissue Eng. Part A 15: 3487-3497. http://dx.doi.org/10.1089/ten.tea.2009.0175 Matsuda N, Morita N, Matsuda K, Watanabe M, et al (1998). Proliferation and differentiation of human osteoblastic cells associated with differential activation of MAP kinases in response to epidermal growth factor, hypoxia, and mechanical stress in vitro. Biochem. Biophys. Res. Commun. 249: 350-354. http://dx.doi.org/10.1006/bbrc.1998.9151 Mattioli-Belmonte M, Teti G, Salvatore V, Focaroli S, et al (2015). Stem cell origin differently affects bone tissue engineering strategies. Front. Physiol. 6: 266. http://dx.doi.org/10.3389/fphys.2015.00266 Park SY, Kim KH, Gwak EH, Rhee SH, et al (2015). Ex vivo bone morphogenetic protein 2 gene delivery using periodontal ligament stem cells for enhanced re-osseointegration in the regenerative treatment of peri-implantitis. J. Biomed. Mater. Res. A 103: 38-47. http://dx.doi.org/10.1002/jbm.a.35145 Qiu X, Zheng M, Song D, Huang L, et al (2016). Notoginsenoside Rb1 inhibits activation of ERK and p38 MAPK pathways induced by hypoxia and hypercapnia. Exp. Ther. Med. 11: 2455-2461. Rodríguez-Carballo E, Gámez B, Ventura F, et al (2016). p38 MAPK Signaling in Osteoblast Differentiation. Front. Cell Dev. Biol. 4: 40. http://dx.doi.org/10.3389/fcell.2016.00040 Seo BM, Miura M, Gronthos S, Bartold PM, et al (2004). Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 364: 149-155. http://dx.doi.org/10.1016/S0140-6736(04)16627-0 Somerman MJ, Young MF, Foster RA, Moehring JM, et al (1990). Characteristics of human periodontal ligament cells in vitro. Arch. Oral Biol. 35: 241-247. http://dx.doi.org/10.1016/0003-9969(90)90062-F Sun Y, Liu WZ, Liu T, Feng X, et al (2015). Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J. Recept. Signal Transduct. Res. 35: 600-604. http://dx.doi.org/10.3109/10799893.2015.1030412 Tang R, Wei F, Wei L, Wang S, et al (2014). Osteogenic differentiated periodontal ligament stem cells maintain their immunomodulatory capacity. J. Tissue Eng. Regen. Med. 8: 226-232. http://dx.doi.org/10.1002/term.1516 Terrizzi AR, Fernandez-Solari J, Lee CM, Bozzini C, et al (2013). Alveolar bone loss associated to periodontal disease in lead intoxicated rats under environmental hypoxia. Arch. Oral Biol. 58: 1407-1414. http://dx.doi.org/10.1016/j.archoralbio.2013.06.010 Trubiani O, Giacoppo S, Ballerini P, Diomede F, et al (2016). Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis. Stem Cell Res. Ther. 7: 1. http://dx.doi.org/10.1186/s13287-015-0253-4 Vandana KL, Desai R, Dalvi PJ, et al (2015). Autologous Stem Cell Application in Periodontal Regeneration Technique (SAI-PRT) Using PDLSCs Directly From an Extracted Tooth···An Insight. Int. J. Stem Cells 8: 235-237. http://dx.doi.org/10.15283/ijsc.2015.8.2.235 Wang Z, Wang W, Xu S, Wang S, et al (2016). The role of MAPK signaling pathway in the Her-2-positive meningiomas. Oncol. Rep. 36: 685-695. Wu RX, Bi CS, Yu Y, Zhang LL, et al (2015). Age-related decline in the matrix contents and functional properties of human periodontal ligament stem cell sheets. Acta Biomater. 22: 70-82. http://dx.doi.org/10.1016/j.actbio.2015.04.024 Wu Y, Yang Y, Yang P, Gu Y, et al (2013). The osteogenic differentiation of PDLSCs is mediated through MEK/ERK and p38 MAPK signalling under hypoxia. Arch. Oral Biol. 58: 1357-1368. http://dx.doi.org/10.1016/j.archoralbio.2013.03.011 Xiao X, Li Y, Zhang G, Gao Y, et al (2012). Detection of bacterial diversity in rat’s periodontitis model under imitational altitude hypoxia environment. Arch. Oral Biol. 57: 23-29. http://dx.doi.org/10.1016/j.archoralbio.2011.07.005 Xu CL, Zheng B, Pei JH, Shen SJ, et al (2016). Embelin induces apoptosis of human gastric carcinoma through inhibition of p38 MAPK and NF-κB signaling pathways. Mol. Med. Rep. 14: 307-312. Yang ZH, Zhang XJ, Dang NN, Ma ZF, et al (2009). Apical tooth germ cell-conditioned medium enhances the differentiation of periodontal ligament stem cells into cementum/periodontal ligament-like tissues. J. Periodontal Res. 44: 199-210. http://dx.doi.org/10.1111/j.1600-0765.2008.01106.x Zhang HY, Liu R, Xing YJ, Xu P, et al (2013). Effects of hypoxia on the proliferation, mineralization and ultrastructure of human periodontal ligament fibroblasts in vitro. Exp. Ther. Med. 6: 1553-1559. Zhang QB, Zhang ZQ, Fang SL, Liu YR, et al (2014). Effects of hypoxia on proliferation and osteogenic differentiation of periodontal ligament stem cells: an in vitro and in vivo study. Genet. Mol. Res. 13: 10204-10214. http://dx.doi.org/10.4238/2014.December.4.15
G. Zhang, Zhou, K. F., Lu, Z. H., Zhang, G., Zhou, K. F., Lu, Z. H., Zhang, G., Zhou, K. F., and Lu, Z. H., Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophil migration and reducing interferon-gamma expression, vol. 15, p. -, 2016.
G. Zhang, Zhou, K. F., Lu, Z. H., Zhang, G., Zhou, K. F., Lu, Z. H., Zhang, G., Zhou, K. F., and Lu, Z. H., Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophil migration and reducing interferon-gamma expression, vol. 15, p. -, 2016.
G. Zhang, Zhou, K. F., Lu, Z. H., Zhang, G., Zhou, K. F., Lu, Z. H., Zhang, G., Zhou, K. F., and Lu, Z. H., Interleukin-17 enhances the removal of respiratory syncytial virus in mice by promoting neutrophil migration and reducing interferon-gamma expression, vol. 15, p. -, 2016.
2013
H. Wang, Zhao, Y., Ma, J., Zhang, G., Mu, Y., Qi, G., Fang, Z., Wang, L., Fan, Q., and Ma, Z., The genetic variant rs401681C/T is associated with the risk of non-small cell lung cancer in a Chinese mainland population, vol. 12. pp. 67-73, 2013.
Bae EY, Lee SY, Kang BK, Lee EJ, et al. (2012). Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population. Respirology 17: 699-706. http://dx.doi.org/10.1111/j.1440-1843.2012.02165.x PMid:22404340   Ginsberg MS (2005). Epidemiology of lung cancer. Semin. Roentgenol. 40: 83-89. http://dx.doi.org/10.1053/j.ro.2005.01.007 PMid:15898406   Girard N, Lou E, Azzoli CG, Reddy R, et al. (2010). Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report. Clin. Cancer Res. 16: 755-763. http://dx.doi.org/10.1158/1078-0432.CCR-09-2437 PMid:20068085 PMCid:2808124   Haiman CA, Chen GK, Vachon CM, Canzian F, et al. (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat. Genet. 43: 1210-1214. http://dx.doi.org/10.1038/ng.985 PMid:22037553 PMCid:3279120   Hardin M, Zielinski J, Wan ES, Hersh CP, et al. (2012). CHRNA3/5, IREB2, and ADCY2 are associated with Severe COPD in Poland. Am. J. Respir. Cell Mol. Biol. [Epub ahead of print]. http://dx.doi.org/10.1165/rcmb.2012-0011OC PMid:22461431   Haugen A, Ryberg D, Mollerup S, Zienolddiny S, et al. (2000). Gene-environment interactions in human lung cancer. Toxicol. Lett. 112-113: 233-237. http://dx.doi.org/10.1016/S0378-4274(99)00275-1   Hung RJ, McKay JD, Gaborieau V, Boffetta P, et al. (2008). A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452: 633-637. http://dx.doi.org/10.1038/nature06885 PMid:18385738   Kiyohara C, Yoshimasu K, Takayama K and Nakanishi Y (2007). Lung cancer susceptibility: are we on our way to identifying a high-risk group? Future Oncol. 3: 617-627. http://dx.doi.org/10.2217/14796694.3.6.617 PMid:18041914   Kollarova H, Janout V and Cizek L (2002). Epidemiology of lung cancer. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub. 146: 103-114. http://dx.doi.org/10.5507/bp.2002.022 PMid:12572908   Lam WK (2005). Lung cancer in Asian women-the environment and genes. Respirology 10: 408-417. http://dx.doi.org/10.1111/j.1440-1843.2005.00723.x PMid:16135162   Law MH, Montgomery GW, Brown KM, Martin NG, et al. (2012). Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk. J. Invest. Dermatol. 132: 485-487. http://dx.doi.org/10.1038/jid.2011.322 PMid:21993562 PMCid:3258346   Liu Z, Li G, Wei S, Niu J, et al. (2010). Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. Carcinogenesis 31: 1977-1981. http://dx.doi.org/10.1093/carcin/bgq179 PMid:20802237 PMCid:2966556   McKay JD, Hung RJ, Gaborieau V, Boffetta P, et al. (2008). Lung cancer susceptibility locus at 5p15.33. Nat. Genet. 40: 1404-1406. http://dx.doi.org/10.1038/ng.254 PMid:18978790 PMCid:2748187   Rafnar T, Sulem P, Stacey SN, Geller F, et al. (2009). Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat. Genet. 41: 221-227. http://dx.doi.org/10.1038/ng.296 PMid:19151717   Sanchez-Cespedes M (2009). Lung cancer biology: a genetic and genomic perspective. Clin. Transl. Oncol. 11: 263-269. http://dx.doi.org/10.1007/s12094-009-0353-7 PMid:19451058   Sugimura H, Tao H, Suzuki M, Mori H, et al. (2011). Genetic susceptibility to lung cancer. Front Biosci. 3: 1463-1477. http://dx.doi.org/10.2741/237   Thill PG, Goswami P, Berchem G and Domon B (2011). Lung cancer statistics in Luxembourg from 1981 to 2008. Bull. Soc. Sci. Med. Grand Duche Luxemb. 43-55. PMid:22272445   Vossen RH, Aten E, Roos A and den Dunnen JT (2009). High-resolution melting analysis (HRMA): more than just sequence variant screening. Hum. Mutat. 30: 860-866. http://dx.doi.org/10.1002/humu.21019 PMid:19418555   Weinrich SL, Pruzan R, Ma L, Ouellette M, et al. (1997). Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17: 498-502. http://dx.doi.org/10.1038/ng1297-498 PMid:9398860   Wu C, Hu Z, Yu D, Huang L, et al. (2009). Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. Cancer Res. 69: 5065-5072. http://dx.doi.org/10.1158/0008-5472.CAN-09-0081 PMid:19491260