Research Article

Related GMR Articles

08/17/2010
Disease susceptibility; MD-2; Single-nucleotide polymorphisms; Tuberculosis

Myeloid differentiation-2 (MD-2) is an essential component of the CD14-TLR4/MD-2 receptor complex involved in microbial cell wall component recognition during infection. Genetic variations in the MD-2 gene may influence human susceptibility to infectious diseases. To date, a predisposition of MD-2 gene variants to contract tuberculosis has not been reported. We investigated whether MD-2 ... more

Y. Xue; Z.Q. Zhao; D. Hong; M.Y. Zhao; Y.X. Zhang; H.J. Wang; Y. Wang; J.C. Li
09/09/2011
Innate immunity; Lectin; Pearl oyster; Pinctada fucata; β-galactoside

Galectins can recognize and specifically bind to β-galactoside residues, playing crucial roles in innate immune responses of vertebrates and invertebrates. We cloned the cDNA of a tandem-repeat galectin from the pearl oyster Pinctada fucata (designated as PoGal2). PoGal2 cDNA is 1347 bp long and consists of a 5ꞌ-untranslated region (UTR) of 3 bp, a 3ꞌ-UTR of 297 bp with one ... more

D.C. Zhang; Y.T. Hu; H.Y. Guo; S.G. Cui; T.F. Su; S.G. Jiang
12/19/2013
Adaptive immunity; Bovine; Flow cytometry; Innate immunity; Leukocyte

Differences in cellular and humoral immunity in Zebu (Bos taurus indicus) and European (B. taurus taurus) cattle breeds, which may be related to differences in resistance or susceptibility to infectious or parasitic diseases, are largely unknown. This study aimed to perform a comparative analysis of innate and adaptive immunity of European (including Holstein, Brown ... more

A.A. Macêdo; A.P.V. Marciano; L.M. Rocha; J.R.F. Alves-Júnior; A.M.C. Faria; J.F.F. Bittar; M.S.S. Araújo; R.L. Santos; O.A. Martins-Filho
02/08/2013
Innate immunity; Molecular evolution; PGLYRP1 gene; Positive selection; Primate; Purifying selection

Short-type peptidoglycan (PGN)-recognition protein 1 (PGLYRP1), an innate immunity protein that directly breaks down the structure of microbial cell wall PGNs, plays an important role both in antibacterial defenses and several inflammatory diseases. To explore the adaptive evolution of the PGLYRP1 gene in primates and provide insight into the function of this antibacterial ... more

W. Liu; Y.F. Yao; L. Zhou; Q.Y. Ni; H.L. Xu
04/29/2014
Collagenolytic serine protease; Eriocheir sinensis; Innate immunity

A novel collagenolytic serine protease (CLSP) was cloned from the hemocytes of the Chinese mitten crab Eriocheir sinensis (Es-CLSP). The full-length cDNA of Es-CLSP contains 990 nucleotides. It encodes a 270-amino acid-long peptide with the mature peptide containing 221 amino acids. It contains the conserved catalytic triad (H, D, and S). Similarity analysis shows that Es-CLSP ... more

Q.Z. Yang; Z.J. Yang; Y. Zhang; X.L. Li; W. Zhang
06/10/2015
Atlantic salmon; Infections pancreatic necrosis virus; Innate immunity; TLR3; Toll-like receptor

Innate pathway activation is fundamental for early anti-viral defense in fish, but currently there is insufficient understanding of how salmonid fish identify viral molecules and activate these pathways. The Toll-like receptor (TLR) is believed to play a crucial role in host defense of pathogenic microbes in the innate immune system. In the present study, the full-length cDNA of Salmo ... more

R. Vidal; R. González; F. Gil
03/13/2015
Innate immunity; Macaca thibetana; Phylogenetic analysis; TLR4 gene; Toll-like receptor

In this study, the complete coding region sequence of an innate immune-related TLR4 gene was obtained from the Tibetan macaque (Macaca thibetana) genome via PCR and direct sequencing. The sequence had a total length of 2481 bp, contained 3 complete exons, and encoded 826 amino acids (AAs); its isoelectric point was 5.703, and the molecular weight was 94.72 kDa. The high ... more

Q.X. Dai; Y.F. Yao; Z.C. Qi; Y. Huang; Q.Y. Ni; M.W. Zhang; H.L. Xu
08/24/2018
Ankylosing spondylitis; CD40 gene; Disease susceptibility; Gene polymorphism

Ankylosing spondylitis (AS) is a potentially disabling form of a systemic chronic inflammatory arthritis affecting mainly the axial skeleton, with or without extraspinal manifestations. The genetic basis of AS is partly known. Moreover, many autoimmunity-related genes have pleiotropic effects. Multiple functional polymorphisms in the genes encoding the tumor ... more

J. Zepa; L. Silamiķele; I. Bulina; V. Lavrentjevs; I. Trapina; J. Klovins; D. Andersone; A. Lejnieks; L. Nikitina-Zake
10/24/2013
Diagnosis; Pulmonary; Sputum; Surfactant protein-A; Tuberculosis

The aim of this study was to explore the diagnostic and differential diagnosis value of surfactant protein-A (SP-A) in the serum and sputum for pulmonary tuberculosis. A total of 101 patients with pulmonary tuberculosis, 85 healthy volunteers, and 30 chronic obstructive pulmonary disease (COPD) patients were divided into pulmonary tuberculosis group, healthy control group, and COPD group ... more

H. Hu; G.L. Teng; L.Z. Gai; Y. Yang; C.J. Zhu
01/24/2013
P2X7; Polymorphism; Tuberculosis

Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala) polymorphisms ... more

G. Bahari; M. Hashemi; M. Taheri; M. Naderi; A. Moazeni-Roodi; H.R. Kouhpayeh; E. Eskandari-Nasab

Pages