Research Article

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02/19/2008
Breast cancer; Chemotherapy; P-glycoprotein; Polymorphism

Primary chemotherapy is a useful strategy for the treatment of locally advanced breast cancer and therefore allows in vivo evaluation of the action of cytotoxic drugs and the possibility of accomplishing conservative breast surgeries, as well as the early treatment of metastasis. Mechanisms of resistance to the drugs include the action of protein associated with the efflux of drugs from ... more

F.F.O. Rodrigues; R.E. Santos; M.B. Melo; M.A.L.G. Silva; A.L. Oliveira; R.L. Rozenowicz; L.B. Ulson; T. Aoki
12/08/2011
Breast cancer; CYP2C19; Genetics; Polymorphism

Cytochrome P450 (CYP) 2C19 metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids, which significantly promote proliferation of cancer cells in vitro and in vivo. We looked for a possible association between human CYP2C19*3 gene polymorphism and breast cancer in the Chinese Han population. In a Chinese Han case-control study of breast cancer ... more

C.Q. Gan; X.Y. Wang; Y.D. Cao; W.X. Ye; H. Liu; Y.Y. Sun
06/11/2010
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family consists of phase II detoxification enzymes that catalyze the conjugation of toxic substances, such as chemotherapeutic agents, to glutathione. We examined whether GSTT1/GSTT1“null”, GSTM1/GSTM1“null” and GSTP1Ile105Ile/GSTP1Ile105Val polymorphisms are associated with different response rates to neoadjuvant ... more

A.L. Oliveira; F.F.O. Rodrigues; R.E. Santos; T. Aoki; M.N. Rocha; C.A. Longui; M.B. Melo
10/31/2014
Breast cancer; Folate; MTHFR; Polymorphism; Vitamin

We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. A matched case-control study was conducted, and 413 patients with newly diagnosed and histologically confirmed breast cancer and 436 controls were recruited. Folate intake, vitamin B6, and vitamin B12 levels were ... more

J.M. He; Y.D. Pu; Y.J. Wu; R. Qin; Q.J. Zhang; Y.S. Sun; W.W. Zheng; L.P. Chen
09/12/2014
Breast cancer; EPHX1; Lung cancer; Meta-analysis; Polymorphism

The association between the microsomal epoxide hydrolase 1 gene (EPHX1) Tyr113His polymorphism and lung cancer and breast cancer risk has been reported in many recent studies, but there is no consensus among the results. Thus, we examined the association between the EPHX1 Tyr113His polymorphism and lung cancer through a meta-analysis. A comprehensive literature search was ... more

X. Tan; Y.Y. Wang; X.Y. Chen; L. Xian; J.J. Guo; G.B. Liang; M.W. Chen
07/24/2014
Breast cancer; Folate; MTHFR; Polymorphism

We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population. A 1:1-matched case-control study was conducted. Two hundred and thirty patients who were newly diagnosed and histologically confirmed breast cancer and 230 controls were enrolled from Xinxiang ... more

Z.G. Wang; W. Cui; L.F. Yang; Y.Q. Zhu; W.H. Wei
01/22/2014
Breast cancer; Drug therapy; Genetic; Glutathione transferase; Polymorphism

The glutathione S-transferase (GST) family comprises phase-II cellular detoxification enzymes that catalyze the conjugation of chemotherapy drugs to glutathione and act on the apoptotic pathway. The aim of this study was to determine whether polymorphisms of the GSTT1, GSTM1, and GSTP1 genes are associated with different rates of overall survival (OS) and disease ... more

A.L. Oliveira; F.F.Oliveira Rodrigues; R.Edos Santos; R.L. Rozenowicz; B. de Melo
06/11/2015
Breast cancer; MicroRNA; Polymorphism

Single-nucleotide polymorphisms in microRNAs (miRNAs) may dramatically affect gene expression and subsequently alter individual susceptibility to cancer, and thus has become a research hotspot for many cancer types, including breast cancer. We recruited 321 breast cancer patients and 290 controls in our study. Four established miRNA single-nucleotide polymorphisms (mir-499 rs3746444 A> ... more

P. Qi; L. Wang; B. Zhou; W.J. Yao; S. Xu; Y. Zhou; Z.B. Xie
06/28/2011
Anadara granosa; mtDNA; Population study; RAPD

We examined genetic variation in blood cockles in an effort to obtain information useful for the sustainability, management, and the stability of this species as a major commodity in the fisheries sector. Ten populations of cockles were sampled from the north to the south of the west coast of peninsular Malaysia. The cockles were collected in collaboration with the Fisheries Research ... more

S.Y. Chee; M.N.S. Azizah; M.N. Devakie
01/28/2014
Ethnic group; Hunan; mtDNA; Origin

Hunan locates in the south-central part of China, to the south of the middle reaches of the Yangtze River and south of Lake Dongting. According to the historical records, the peopling of Hunan by modern human ancestors can ascend to 40 thousand years ago. Thus, to trace the ancient maternal components can offer further insight into the origin of south-central China. In this study, we ... more

H.Y. Zhou; H.W. Wang; S.N. Tan; Y. Chen; W.L. Wang; H.X. Tao; Z.C. Yin; Y.H. Zou; S.M. Ouyang; B. Ni

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