Research Article

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Breast cancer; Differentially expressed genes; Gene coexpression network analysis; Pathway analysis

The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed genes (DEGs) between breast cancer and normal control were ... more

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Breast cancer; Fibrocystic changes; Malignant breast lesions; MDR1; P-glycoprotein

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N.M. Macías-Gómez; M. Gutierrez-Angulo; E. Leal-Ugarte; L. Ramírez-Reyes; J. Peregrina-Sandoval; J.P. Meza-Espinoza; R. Solano; dela Luz Ayala-Madrigal; S. Telles
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Breast cancer; Clinicopathological characteristics; Hypoxia-inducible factor-2α; Prognosis

Malignant cells show increased invasion potency in vitro and in vivo. This process is considered to be mediated by matrix-metalloproteases (MMPs). Hypoxia-inducible factor-2α (HIF-2α) may upregulate MMP-2 expression; however, little is known about the correlation between HIF-2α and MMP-2 expressions in breast cancer. The current study investigated this correlation ... more

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Breast cancer is one of the most frequently diagnosed cancer in women worldwide, and we conducted a case-control study by genotyping seven potentially functional SNPs, three in ERCC1 and four in XPF, in a Chinese population of 417 breast cancer cases and 417 cancer-free controls. Three SNPs in ERCC1 and four SNPs in XPF were genotyped by using the Taqman Universal PCR Master Mix in the ... more

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BRCA1 gene; Breast cancer; Clinical samples; Exon sequencing; Mutation

Germline mutations in the BRCA1 gene are known predictive markers for the development of hereditary breast cancer. Nevertheless, no comprehensive study has been performed targeting the presence and relevance of BRCA1 mutations in Moroccan breast cancer patients. We here present an analysis of BRCA1 gene regions (exon 2 and exon 11a/b) of 50 female Moroccan breast cancer ... more

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Glutathione S-transferases (GSTs) are a family of phase II metabolizing enzymes involved in carcinogen detoxification and the metabolism of various bioactive compounds. Several genes that code for these enzymes are polymorphic in an ethnicity-dependent manner, with particular genotypes previously associated with an increased risk of breast cancer. The purpose of this study was to ... more

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The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to ... more

A. Ramos-Silva; L.E. Figuera; O.M. Soto-Quintana; A.M. Puebla-Pérez; R. Ramírez-Patiño; I. Gutiérrez-Hurtado; D.I. Carrillo-Moreno; G.M. Zúñiga-González; I.P. Dávalos-Rodríguez; M.P. Gallegos-Arreola
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Breast cancer; Immunohistochemistry; Special AT-rich sequence binding protein 1

Special AT-rich sequence binding protein 1 (SATB1) is a recently discovered gene regulator that can promote the growth and metastasis of breast cancer. However, its expression in different stages of breast cancer development have not been examined. We explored the role of SATB1 in the development of breast cancer by detecting SATB1 expression levels in different stages of breast cancer. ... more

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Nondestructive preoperative breast imaging techniques are widely used for breast cancer testing and diagnosis. This study aimed to evaluate the feasibility and efficacy of quantitative diagnosis via the thermal analysis of abnormal metabolism. Nine hundred forty-eight women who underwent breast biopsy from 2009 to 2013 were investigated. Thermal analysis was used to calculate the internal ... more

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