Research Article

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11/29/2011
Gene polymorphism; Meta-analysis; p53 codon 72; Prostate cancer

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on all the studies showed no significant association ... more

M.S. Li; J.L. Liu; Y. Wu; P. Wang; H. Teng
01/08/2014
Gene polymorphism; Head and neck carcinomas; Meta-analysis; p53 codon 72

Genetic factors have been shown to play a role in the development of head and neck cancers (HNCs). However, studies investigating the association between the TP53 Arg72Pro polymorphism and HNCs susceptibility have yielded conflicting results. Hence, we performed a meta-analysis of all eligible studies (up to January 1, 2012) to derive a more precise estimation of this association ... more

W.H. Ren; D.K. Jiang; Y. Pei; S.Q. Wang; X.M. Yang; L. Yu
11/08/2011
Gene polymorphism; Liver cirrhosis; Meta-analysis; Risk; Tumor necrosis factor

TNF-α is a potential proinflammatory cytokine that plays an important role in the pathogenesis of liver cirrhosis. We investigated a possible association between TNF-α -308G>A polymorphism and liver cirrhosis risk by conducting a meta-analysis. Publications addressing the association between TNF-α -308G>A and liver cirrhosis risk were selected from the Pubmed and Embase databases. ... more

D. Chen; J.L. Liu; Y. Liu; J. Zhu; S.W. Wang
12/04/2013
Congenital heart defects; Gene polymorphism; Meta-analysis; Methylenetetrahydrofolate reductase

Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relationship between the C677T ... more

K.H. Chen; L.L. Chen; W.G. Li; Y. Fang; G.Y. Huang
12/17/2012
Gene polymorphism; LOC387715/ARMS2; Meta-analysis; Polypoidal choroidal vasculopathy

We investigated the association between the LOC387715/ARMS2 polymorphism (rs10490924 G>T) and susceptibility to polypoidal choroidal vasculopathy (PCV) through a meta-analysis of 1446 cases and 3255 controls from eight case-control studies. The genetic effect of the LOC387715/ARMS2 rs10490924 G>T polymorphism on PCV was assessed by calculating pooled odds ratios (ORs) with 95% ... more

J.J. Jiang; X. Wu; P. Zhou; W.Z. Yu; L.Z. Huang; X.X. Li
02/08/2012
Dopamine D2 receptor; Gene polymorphism; Meta-analysis; Schizophrenia

Numerous studies have evaluated the association between Ser311Cys (rs1801028, C>G) polymorphism of the dopamine D2 receptor (DRD2) gene and schizophrenia risk. However, the specific association is still controversial. We examined whether DRD2 Ser311Cys polymorphism confers schizophrenia risk in Asian populations. Sixteen studies were retrieved reporting on a total of 2268 schizophrenia ... more

Z.W. Liu; J.L. Liu; Y. An; L. Zhang; Y.M. Wang
11/28/2014
Bladder cancer; Gene polymorphism; Meta-analysis; XRCC1 Arg399Gln

We examined whether the X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism is a risk factor for bladder cancer by conducting a meta-analysis. We searched the Pubmed and Embase databases for study retrieval. This meta-analysis examined 16 case-control studies, including 892 prostate cancer cases and 1020 healthy controls. Meta-analysis results based on these studies ... more

L.M. Dong; X.Y. Zhang; H. Teng; M.S. Li; P. Wang
09/12/2014
C677T; Gene polymorphism; Meta-analysis; Postmenopausal women

Numerous studies have evaluated the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis of the association between MTHFR C677T polymorphism and osteoporotic fracture risk in postmenopausal women. Only seven case-control studies were retrieved, with a total of 4258 ... more

J.Z. Guan; M. Wu; Y.Z. Xiao; J.S. Zhou; Z.D. Wang
04/22/2015
Angiotensinogen; Gene polymorphism; Meta-analysis; Myocardial infarction

Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to ... more

P.Y. Hu; Y.W. Wang; X.H. Pang; H.W. Wang
12/08/2011
Corneodesmosin; Gene polymorphism; Meta-analysis; Psoriasis; Risk

Previous studies investigating the association between corneodesmosin (CDSN) polymorphisms and psoriasis risk have provided inconsistent results. The aim of our study was to clarify the effects of CDSN -619C/T polymorphism on psoriasis risk by conducting a meta-analysis. We conducted searches of the published literature in Pubmed and Embase databases up to October 2010. Six studies with a ... more

Y. Wu; B. Wang; J.L. Liu; X.H. Gao; H.D. Chen; Y.H. Li

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