Research Article

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11/30/2010
Bone mineral density; Bone morphogenetic protein 2 and 4; Genetic association; Osteoporosis; Single-nucleotide polymorphism

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the ... more

Z.S. Özkan; D. Deveci; E. Önalan; H. Yüce
12/14/2010
Cloning; Litopenaeus vannamei; Ryanodine receptor; Single-nucleotide polymorphism

Ryanodine receptor/calcium release channel is a large protein that plays an essential role in muscle contraction; mutations in the ryanodine receptor gene affect sensitivity to stress. As a first step towards investigating the relationship between the ryanodine receptor and shrimp cramped muscle syndrome, we cloned, partially sequenced, and examined single-nucleotide polymorphisms (SNPs) ... more

X.H. Chen; D.G. Zeng; N. Ma
11/23/2010
Adrenal cortex hormones; Corticosteroids; Dexamethasone; Glucocorticoid sensitivity inflammation; Nuclear factor kappa-B; Rheumatoid arthritis

We measured NF-κB, IKK, c-Fos, and GRαmRNA expression and in vivo glucocorticoid sensitivity in patients with rheumatoid arthritis. A very low dose intravenous dexamethasone suppression test and real-time PCR quantitation of mRNA of these genes were performed on blood samples from 21 rheumatoid arthritis patients who were not on glucocorticoids during the ... more

L.O. Cavalcante; M.R. Melo; V.G. Dinis; R.B. Castro; B.D.B. Souza; C.A. Longui
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L55M polymorphism; Paraoxonase; PON1; Rheumatoid arthritis

araoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subjects, using the tetra-amplification refractory mutation system- ... more

M. Hashemi; A.K. Moazeni-Roodi; A. Fazaeli; M. Sandoughi; M. Taheri; G.R. Bardestani; Z. Zakeri; D.M. Kordi-Tamandani; S. Ghavami
02/23/2010
Paraoxonase; PON1; Q192R polymorphism; Rheumatoid arthritis

Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis. The Q192R polymorphism in 88 rheumatoid arthritis patients and 78 ... more

M. Hashemi; A.K. Moazeni-Roodi; A. Fazaeli; M. Sandoughi; G.R. Bardestani; D.M. Kordi-Tamandani; S. Ghavami
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GSEA; Osteoarthritis; PPAR signaling pathway; Rheumatoid arthritis

Both rheumatoid arthritis (RA) and osteoarthritis (OA) are complex diseases. Studies and treatment of RA and OA have mainly focused on individual factors. However, there is still no clear understanding of their causes and adequate treatment alternatives are still being sought. We applied gene set-enrichment analysis to microarray datasets of RA and OA to look for regulatory mechanisms. We ... more

C.Q. Yi; C.H. Ma; Z.P. Xie; Y. Cao; G.Q. Zhang; X.K. Zhou; Z.Q. Liu
06/11/2013
GNAQ; Han Chinese population; Polymorphism; Rheumatoid arthritis

Mice that lose Gαq from their immune system can spontaneously develop inflammatory arthritis. Gαq expression in the peripheral blood lymphocytes of rheumatoid arthritis (RA) patients is significantly decreased in comparison to that in healthy individuals, and reduced Gαq expression is closely correlated with RA disease activ­ity. These indicate that Gαq plays critical roles in the ... more

Y. Li; Y. Wang; Y. He; D. Wang; L. Deng; Y. Du; G. Shi
04/25/2013
CD86; CTLA-4; Rheumatoid arthritis; Single nucleotide polymorphisms

The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We ... more

C.P. Liu; J.A. Jiang; T. Wang; X.M. Liu; L. Gao; R.R. Zhu; Y. Shen; M. Wu; T. Xu; X.G. Zhang
02/27/2013
Association study; IL-2RA; IL-2RB; Rheumatoid arthritis

Polymorphisms in IL-2RA and IL-2RB genes have been reported to confer susceptibility to rheumatoid arthritis (RA) in European populations. We investigated a possilbe association between SNPs in IL-2RA and IL-2RB genes and RA in a Han Chinese population. rs2104286 in IL-2RA and rs743777 in IL-2RB genes were genotyped in a Han Chinese ... more

J. Zhu; F. He; D.D. Zhang; J.Y. Yang; J. Cheng; R. Wu; B. Gong; X.Q. Liu; S. Ma; B. Zhou
02/07/2013
Polymorphism; Rheumatoid arthritis; Toll-like receptor

We investigated whether Toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis and whether they influence clinical characteristics of rheumatoid arthritis. Studies were considered relevant for our meta-analysis if at least two comparisons of an issue were available. Eleven studies with 2078 patients with rheumatoid arthritis and 2581 controls were ... more

Y.H. Lee; S.C. Bae; G.G. Song

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